Simonsson Maria, Markkula Andrea, Bendahl Pär-Ola, Rose Carsten, Ingvar Christian, Jernström Helena
Department of Clinical Sciences, Division of Oncology and Pathology, Barngatan 2B, SE-22185 Lund, Sweden.
CREATE Health and Department of Immunotechnology, Lund University, Medicon Village, Building 406, Lund, Sweden.
Springerplus. 2014 May 22;3:261. doi: 10.1186/2193-1801-3-261. eCollection 2014.
To investigate the association between pre- and postoperative alcohol consumption and risk for early breast cancer events, since the association between alcohol consumption and prognosis in breast cancer patients is unclear.
Alcohol consumption was recorded for 934 primary breast cancer patients who underwent breast cancer surgery in Lund, Sweden, between 2002 and 2011 and were followed until December 31(st) 2012. Clinical data were obtained from medical records and population registries. Pre- and postoperative alcohol consumption was analyzed in relation to risk for early events.
Median follow-up time was 3.03 years and 100 breast cancer events, 65 distant metastases, and 76 deaths occurred. Compared to no consumption, any preoperative alcohol consumption was weakly associated with lower risk for early events, adjusted HR 0.69 (0.45-1.04), distant metastases, 0.60 (0.36-1.00) and death, 0.62 (0.38-1.01). In the 572 patients without axillary lymph node involvement, any alcohol consumption was not associated with risk for early events. However, in the 360 patients with axillary lymph node involvement, preoperative alcohol consumption was associated with lower risk for early events (adjusted HR 0.43 0.24-0.77; P interaction = 0.01).
Pre- and postoperative alcohol consumption was weakly associated with lower risk for early breast cancer events. The data does not support recommending that all breast cancer patients abstain from low to moderate alcohol consumption.
鉴于饮酒与乳腺癌患者预后之间的关联尚不清楚，本研究旨在调查术前和术后饮酒与早期乳腺癌事件风险之间的关联。
记录了934例2002年至2011年在瑞典隆德接受乳腺癌手术并随访至2012年12月31日的原发性乳腺癌患者的饮酒情况。临床数据来自医疗记录和人口登记处。分析术前和术后饮酒与早期事件风险的关系。
中位随访时间为3.03年，发生了100例乳腺癌事件、65例远处转移和76例死亡。与不饮酒相比，任何术前饮酒与早期事件风险降低呈弱相关，校正后风险比（HR）为0.69（0.45-1.04），远处转移为0.60（0.36-1.00），死亡为0.62（0.38-1.01）。在572例无腋窝淋巴结受累的患者中，任何饮酒与早期事件风险均无关联。然而，在360例有腋窝淋巴结受累的患者中，术前饮酒与早期事件风险降低相关（校正后HR为0.43，0.24-0.77；P交互作用=0.01）。
术前和术后饮酒与早期乳腺癌事件风险降低呈弱相关。数据不支持建议所有乳腺癌患者戒除低至中度饮酒。
