急性症状性癫痫发作与全身性疾病。
Acute symptomatic seizures and systemic illness.
作者信息
Karceski Steven
出版信息
Continuum (Minneap Minn). 2014 Jun;20(3 Neurology of Systemic Disease):614-23. doi: 10.1212/01.CON.0000450969.61204.6f.
PURPOSE OF REVIEW
This article addresses the occurrence of acute symptomatic seizures in the setting of many medical illnesses.
RECENT FINDINGS
Many medical illnesses can cause seizures. Metabolic derangements, such as disorders of serum glucose metabolism, cause seizures, as well as other neurologic manifestations. Many medicines (such as antibiotics, antivirals, antidepressants, and antipsychotics), whether used at typical doses or in overdosage, can lead to acute symptomatic seizures.
SUMMARY
Acute symptomatic seizures occur most often in illnesses that directly injure the brain. Trauma, stroke, CNS tumors, and CNS infection very commonly cause seizures. However, many medical illnesses do not directly injure the brain but lead to neurologic signs and symptoms, such as seizures. Recognizing these effects, especially in critically ill patients, is important for optimizing medical care.
综述目的
本文探讨了在多种内科疾病背景下急性症状性癫痫发作的情况。
最新发现
许多内科疾病可导致癫痫发作。代谢紊乱，如血清葡萄糖代谢紊乱，可引起癫痫发作以及其他神经学表现。许多药物（如抗生素、抗病毒药、抗抑郁药和抗精神病药），无论以常规剂量使用还是过量使用，都可导致急性症状性癫痫发作。
总结
急性症状性癫痫发作最常发生于直接损伤大脑的疾病中。创伤、中风、中枢神经系统肿瘤和中枢神经系统感染非常常见地导致癫痫发作。然而，许多内科疾病并不直接损伤大脑，但会导致神经学体征和症状，如癫痫发作。认识到这些影响，尤其是在危重症患者中，对于优化医疗护理很重要。
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