Stocker Ryan P J, Cieply Marissa A, Paul Benjamin, Khan Hassen, Henry Luke, Kontos Anthony P, Germain Anne
University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Counseling Psychology, Chatham University, Pittsburgh, PA, USA.
University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Neuroimage. 2014 Oct 1;99:207-14. doi: 10.1016/j.neuroimage.2014.05.067. Epub 2014 Jun 2.
Traumatic brain injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinnings of this relationship in military veterans, [(18)F]-fluorodeoxyglucose positron emission tomography (FDG PET) was used to compare mTBI-related changes in relative cerebral metabolic rate of glucose (rCMRglc) during wakefulness, Rapid Eye Movement (REM) sleep, and non-REM (NREM) sleep, after adjusting for the effects of posttraumatic stress (PTS). Fourteen veterans with a history of blast exposure and/or mTBI (B/mTBI) (age 27.5±3.9) and eleven veterans with no history (No B/mTBI) (age 28.1±4.3) completed FDG PET studies during wakefulness, REM sleep, and NREM sleep. Whole-brain analyses were conducted using Statistical Parametric Mapping (SPM8). Between group comparisons revealed that B/mTBI was associated with significantly lower rCMRglc during wakefulness and REM sleep in the amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, uncus, culmen, visual association cortices, and midline medial frontal cortices. These results suggest that alterations in neurobiological networks during wakefulness and REM sleep subsequent to B/mTBI exposure may contribute to chronic sleep disturbances and differ in individuals with acute symptoms.
创伤性脑损伤（TBI）是持久自由行动和伊拉克自由行动中的典型创伤，可由钝性头部外伤或暴露于爆炸/冲击波导致。虽然TBI会影响睡眠，但TBI与睡眠之间的神经生物学基础在很大程度上尚不清楚。为了研究军事退伍军人中这种关系的神经生物学基础，在调整创伤后应激（PTS）的影响后，使用[18F] - 氟脱氧葡萄糖正电子发射断层扫描（FDG PET）来比较轻度创伤性脑损伤（mTBI）相关的清醒期、快速眼动（REM）睡眠期和非快速眼动（NREM）睡眠期的相对脑葡萄糖代谢率（rCMRglc）变化。14名有爆炸暴露和/或mTBI病史（B/mTBI）的退伍军人（年龄27.5±3.9）和11名无病史的退伍军人（无B/mTBI）（年龄28.1±4.3）在清醒期、REM睡眠期和NREM睡眠期完成了FDG PET研究。使用统计参数映射（SPM8）进行全脑分析。组间比较显示，B/mTBI与杏仁核、海马体、海马旁回、丘脑、脑岛、钩回、山顶、视觉联合皮层和中线内侧额叶皮层在清醒期和REM睡眠期的rCMRglc显著降低有关。这些结果表明，B/mTBI暴露后清醒期和REM睡眠期神经生物学网络的改变可能导致慢性睡眠障碍，且在有急性症状的个体中有所不同。
