Li Qing-Lan, Gu Wen-Xing, Gao Hui, Yang Ying-Wei
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P.R. China.
Chem Commun (Camb). 2014 Nov 11;50(87):13201-15. doi: 10.1039/c4cc03036b. Epub 2014 Jun 4.
In this feature article, we give an overview of the preparation and application of self-assembled architectures based on an emerging area of polymers, i.e., poly(glycidyl methacrylate)s (PGMAs) and their derivatives. A series of PGMA-based aggregates and hybrids, such as micelles, reverse micelles, capsules, nanoparticles, and inorganic-organic hybrid materials, has been constructed, and diverse morphologies were formed, driven by hydrophobic interactions, hydrogen bonding, ionic complexation, host-guest interactions, etc. In particular, the assemblies have shown great potential applications as drug vectors, gene vectors, solubilizing agents, antimicrobial agent, and so forth. Herein, the general guidelines are elaborately selected from literature examples and partially from our own. Although still in its infancy, self-assembly of PGMA-based polymers is expected to become a hot topic in polymer chemistry and materials science.
在这篇专题文章中，我们概述了基于聚合物新兴领域即聚甲基丙烯酸缩水甘油酯（PGMAs）及其衍生物的自组装结构的制备与应用。一系列基于PGMA的聚集体和杂化材料，如胶束、反胶束、胶囊、纳米颗粒以及无机-有机杂化材料，已经被构建出来，并且在疏水相互作用、氢键、离子络合、主客体相互作用等驱动下形成了多样的形态。特别地，这些组装体已显示出作为药物载体、基因载体、增溶剂、抗菌剂等的巨大潜在应用。在此，通用指南是从文献实例中精心挑选出来的，部分也来自我们自己的研究。尽管基于PGMA的聚合物的自组装仍处于起步阶段，但有望成为聚合物化学和材料科学中的一个热门话题。
