International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Chem Rec. 2018 Jan;18(1):45-54. doi: 10.1002/tcr.201700036. Epub 2017 Jul 4.
Researches on cargo delivery systems have received burgeoning attention and advanced rapidly. For synthetic nanodevices, polymer nanoassemblies and their inorganic-organic hybrid materials, especially smart mesoporous silica nanoparticle (MSN)-polymer hybrids (e. g., MSN@PGMAs), have attracted increasing attention in recent years. Their superior characteristics and unique features such as dynamic transition of morphology endow them the ability to efficiently entrap cargo molecules and undergo smart cargo delivery and release in response to various external stimuli. In this Personal Account, we present our recent research progress in the construction of cargo delivery systems based on polymers, poly(glycidyl methacrylate) (PGMA) and its derivatives in particular, ranging from polymer nanoparticles, reverse micelles, to vesicles and reverse vesicles, and their performance in the delivery and controlled release of model molecules and therapeutic agents. Significantly, MSN-PGMA hybrid nanoassemblies (MSN@PGMAs), constructed with the aid of atom transfer radical polymerization, host-guest interactions, or layer-by-layer self-assembly techniques, and their potential bio-related applications and anti-bacterial applications as new nanocarriers are reviewed. Finally, the prospects and challenges of such nanoplatforms are also discussed.
货物输送系统的研究受到了越来越多的关注，并得到了快速发展。对于合成纳米器件、聚合物纳米组装体及其无机-有机杂化材料，特别是智能介孔硅纳米颗粒（MSN）-聚合物杂化物（例如，MSN@PGMAs），近年来引起了越来越多的关注。它们具有优越的特性和独特的特点，如形态的动态转变，使它们能够有效地捕获货物分子，并能响应各种外部刺激进行智能货物输送和释放。在这篇个人观点中，我们介绍了我们最近在基于聚合物的货物输送系统构建方面的研究进展，特别是聚（甲基丙烯酸缩水甘油酯）（PGMA）及其衍生物，包括聚合物纳米颗粒、反胶束、囊泡和反囊泡，以及它们在模型分子和治疗剂的输送和控制释放方面的性能。值得注意的是，MSN-PGMA 杂化纳米组装体（MSN@PGMAs）是在原子转移自由基聚合、主客体相互作用或层层自组装技术的辅助下构建的，它们作为新型纳米载体在生物相关应用和抗菌应用方面具有很大的潜力。最后，还讨论了这种纳米平台的前景和挑战。
