Garcia Sarah, Calvo Dayana, Spitznagel Mary Beth, Sweet Lawrence, Josephson Richard, Hughes Joel, Gunstad John
1Kent State University , Kent, OH , USA.
Int J Neurosci. 2015 Apr;125(4):247-52. doi: 10.3109/00207454.2014.928290. Epub 2014 Jun 27.
PURPOSE/AIM: Past work shows an inconsistent relationship between dairy intake and cognition in healthy older adults. A cross-sectional design was conducted to examine dairy consumption, cognitive dysfunction, and cerebral blood flow in a sample of older adults with heart failure (HF) to clarify their association in this population at high risk for adverse neurocognitive outcomes.
A total of 86 older adults with HF (70.39 ± 9.51 years; 33.1% female) underwent neuropsychological testing, transcranial Doppler (TCD) sonography to quantify cerebral blood flow. Dairy intake was quantified using a brief self-report questionnaire.
Partial correlations between the dairy consumption questionnaire and neuropsychological tests were conducted adjusting for HF severity, age, and sex. Contrary to expectations, results showed greater dairy intake was associated with poorer memory (r = -0.21, p = 0.01) and higher pulsatility index in the medial cerebral artery (r = -0.17, p = 0.05).
Results suggest that greater dairy intake was associated with poorer memory performance in older adults with HF. Several possible explanations for these findings exist, including the contribution of high-fat dairy to underlying physiological processes that promote vascular cognitive impairment. Prospective studies employing objective measures specific to high and low fat dairy are needed to clarify this possibility.
过去的研究表明，健康老年人的乳制品摄入量与认知之间的关系并不一致。本研究采用横断面设计，对心力衰竭（HF）老年患者样本中的乳制品消费、认知功能障碍和脑血流量进行检查，以阐明它们在这一具有不良神经认知结局高风险人群中的关联。
共有86名HF老年患者（70.39±9.51岁；女性占33.1%）接受了神经心理学测试、经颅多普勒（TCD）超声检查以量化脑血流量。乳制品摄入量通过一份简短的自我报告问卷进行量化。
在对HF严重程度、年龄和性别进行校正后，对乳制品消费问卷与神经心理学测试之间进行了偏相关性分析。与预期相反，结果显示较高的乳制品摄入量与较差的记忆力（r = -0.21，p = 0.01）以及大脑中动脉较高的搏动指数（r = -0.17，p = 0.05）相关。
结果表明，较高的乳制品摄入量与HF老年患者较差的记忆表现相关。这些发现存在几种可能的解释，包括高脂肪乳制品对促进血管性认知障碍的潜在生理过程的影响。需要采用针对高脂肪和低脂肪乳制品的客观测量方法的前瞻性研究来阐明这种可能性。
