Zhang L, Sun J, Liu Z, Dai Y, Luo Z, Jiang X, Li Z, Li Y, Cao P, Zhou Y, Zeng Z, Tang A, Li X, Li X, Xiang J, Li G
(J. Xiang) Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, P.R. China.
Curr Mol Med. 2014;14(6):749-61. doi: 10.2174/1566524014666140724102301.
Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of macrophages. Nitric oxide produced by BMSCs in tumor environment could translocate caldesmon to podosome in Ca2+/calmodulin manner and promoted metastatic ability of NPC cells through invadopodia formation, with which the NPC cells degrade the extracellular matrix. Thus, we concluded that the BMSCs promoted cell migration and invasion through nitric oxide-induced paracrine signals.
骨髓间充质干细胞（BMSCs）可被募集至肿瘤部位并整合到肿瘤基质中。当与BMSCs共培养时，原本转移能力较弱的鼻咽癌细胞（NPC）显示出转移能力增强。肿瘤环境中的BMSCs表现出巨噬细胞的特征。肿瘤环境中BMSCs产生的一氧化氮可以Ca2+/钙调蛋白的方式将钙调蛋白转运至足体，并通过形成侵袭伪足促进NPC细胞的转移能力，NPC细胞借此降解细胞外基质。因此，我们得出结论，BMSCs通过一氧化氮诱导的旁分泌信号促进细胞迁移和侵袭。
