Schmidt A, Küppers R
Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Virchowstr. 173, 45122 Essen, Germany.
Curr Mol Med. 2014;14(5):580-97. doi: 10.2174/1566524014666140603095414.
MicroRNAs (miRNAs) are a class of small (18~25 nucleotides long) non-coding RNAs that regulate gene expression on the post-transcriptional level. During the last decade, the field of miRNA research has been exponentially expanding, revealing the widespread role of these molecules in numerous biological processes. Aberrant miRNA expression has been documented in multiple haematologic malignancies, including B cell lymphomas. There is compelling evidence that miRNAs can function as oncogenes or tumor suppressor genes in lymphoid malignancies. In this review, we recapitulate the current knowledge of miRNA expression in B cell malignancies and discuss the accumulating evidence for a major role of miRNA deregulation in the development of B cell-derived lymphoid tumors.
微小RNA（miRNA）是一类小的（18至25个核苷酸长）非编码RNA，它们在转录后水平上调节基因表达。在过去十年中，miRNA研究领域呈指数级扩展，揭示了这些分子在众多生物学过程中的广泛作用。在包括B细胞淋巴瘤在内的多种血液系统恶性肿瘤中，已记录到miRNA表达异常。有令人信服的证据表明，miRNA在淋巴恶性肿瘤中可作为癌基因或肿瘤抑制基因发挥作用。在本综述中，我们总结了目前关于B细胞恶性肿瘤中miRNA表达的知识，并讨论了越来越多的证据表明miRNA失调在B细胞源性淋巴瘤发生中起主要作用。
