UNIVERSITY OF DUISBURG-ESSEN.
Blood. 2014 Jul 10;124(2):158-9. doi: 10.1182/blood-2014-06-578864.
In this issue of , de Yébenes et al identify miR-217 as a promoter of the germinal center reaction, partly by suppressing the DNA damage response. Overactivity of miR-217 is hence potentially dangerous, and, indeed, its uncontrolled expression causes lymphomas.
在本期 中,de Yébenes 等人发现 miR-217 可部分通过抑制 DNA 损伤反应来促进生发中心反应。因此,miR-217 的过度活跃可能是危险的,事实上,其不受控制的表达会导致淋巴瘤。