从一种抑制脂多糖诱导的一氧化氮产生的真菌中分离出一种新型的派西利定类似物吡派西利定。
Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production.
作者信息
Matsui Chino, Ikeda Yoko, Iinuma Hironobu, Kushida Nobuaki, Kunisada Takao, Simizu Siro, Umezawa Kazuo
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Bioscience Associates, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2014 Nov;67(11):787-90. doi: 10.1038/ja.2014.63. Epub 2014 Jun 4.
We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.
我们使用小鼠巨噬细胞系RAW264.7筛选了微生物培养滤液中的一氧化氮（NO）生成抑制剂。结果，从谢氏拟青霉的培养滤液中分离出了卷须霉素、21-异戊烯基卷须霉素和一种新型卷须霉素类似物。该新型类似物具有一个额外的二氢吡喃环，被命名为吡咯卷须霉素。该化合物抑制NO生成的毒性低于卷须霉素。
Zotero 插件