从Decne根际土壤中分离出的sp. HFF16的抗糖尿病吲哚-萜类化合物。

Anti-Diabetic Indole-Terpenoids From sp. HFF16 Isolated From the Rhizosphere Soil of Decne.

作者信息

Xiao Na, Xu Yiru, Zhang Xinru, Li Haonan, Zhang Shengnan, Xiao Ang, Yu Jinyi, Yang Mingtian, Lv Fujin, Zhang Mingyu, Hao Gangping, Chen Guotong, Zhou Liman, Kong Fandong, Pan Guojun

机构信息

State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, China.

College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.

出版信息

Front Chem. 2022 Feb 8;9:792810. doi: 10.3389/fchem.2021.792810. eCollection 2021.

Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research, five new indole-terpenoids (-), named encindolenes D-H, were isolated from the fungus sp. HFF16 from the rhizosphere soil of Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the anti-diabetic activity assay, compounds could inhibit the hepatic glucose production with EC values of 17.6, 30.1, 21.3, 9.6, and 9.9 M, respectively, and decrease the cAMP contents in glucagon-induced HepG2 cells.