Dzwonkowska A, Hubner H
Pol J Occup Med. 1989;2(3):286-93.
Mutagenic activity of eight commercial insecticides previously tested with in vivo chromosomal aberrations test after intraperitoneal treatment, was studied with the same test using per os administration of pesticides. Chromosomal aberrations were analyzed in the bone marrow cells of Syrian hamsters. It was shown that six pesticides induced a statistically significant increase in the number of chromosomal aberrations: Bi 58 EC, Metasystox (I) forte, Sadofos 30, Nogos 50 EC, Foschlor 25 and Thiodan 35. These insecticides induced two main types of aberrations: chromatid gaps and chromatid breaks. Gamacarbatox and Propotox M were nonmutagenic in the test.
在之前经腹腔注射进行体内染色体畸变试验检测的8种商用杀虫剂中，用经口给予杀虫剂的相同试验研究了其致突变活性。在叙利亚仓鼠的骨髓细胞中分析染色体畸变情况。结果表明，6种杀虫剂可使染色体畸变数量出现统计学上的显著增加：Bi 58乳油、速灭磷（I）强力剂、三硫磷30、久效磷50乳油、氯甲磷25和硫丹35。这些杀虫剂诱发两种主要类型的畸变：染色单体裂隙和染色单体断裂。加马卡巴托克斯和丙虫磷M在该试验中无致突变性。
