Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Transl Oncol. 2014 Aug;7(4):503-7. doi: 10.1016/j.tranon.2014.05.001. Epub 2014 Jun 2.
BACKGROUND/AIMS: Biological and epidemiological data suggest that vitamin D levels may influence cancer development. Several single nucleotide polymorphisms have been described in the vitamin D receptor (VDR) gene in association with cancer risk. We aimed to investigate the association of VDR gene polymorphisms with hepatocellular carcinoma (HCC) development in chronic hepatitis C patients.
In a cross-sectional, hospital-based setting, 340 patients (201 chronic hepatitis, 47 cirrhosis and 92 HCC) and 100 healthy controls receiving VDR genotyping (bat-haplotype: BsmI rs1544410 C, ApaI rs7975232 C and TaqI rs731236 A) were enrolled.
Patients with HCC had a higher frequency of ApaI CC genotype (P = 0.027) and bAt[CCA]-haplotype (P = 0.037) as compared to control subjects. There were no differences in BsmI and TaqI polymorphisms between two groups. In patients with chronic hepatitis C, HCC subjects had a higher frequency of ApaI CC genotype and bAt[CCA]-haplotype than those with chronic hepatitis (P = 0.001 and 0.002, respectively) and cirrhosis (P = 0.019 and 0.026, respectively). After adjusting age and sex, logistic regression analysis showed that ApaI CC genotype (odds ratio: 3.02, 95% confident interval: 1.65-5.51) was independently associated with HCC development.
VDR ApaI polymorphism plays a role in the development of HCC among chronic hepatitis C patients. Further explorations of this finding and its implications are required.
背景/目的：生物学和流行病学数据表明，维生素 D 水平可能会影响癌症的发生。维生素 D 受体（VDR）基因中已有多种单核苷酸多态性与癌症风险相关。我们旨在研究 VDR 基因多态性与慢性丙型肝炎患者肝癌（HCC）发展的关系。
在一项横断面、基于医院的研究中，纳入了 340 名患者（201 名慢性肝炎、47 名肝硬化和 92 名 HCC）和 100 名健康对照者进行 VDR 基因分型（蝙蝠单倍型：BsmI rs1544410 C、ApaI rs7975232 C 和 TaqI rs731236 A）。
与对照组相比，HCC 患者 ApaI CC 基因型（P = 0.027）和 bAt[CCA]-单倍型（P = 0.037）的频率更高。两组之间 BsmI 和 TaqI 多态性无差异。在慢性丙型肝炎患者中，HCC 患者的 ApaI CC 基因型和 bAt[CCA]-单倍型频率高于慢性肝炎患者（P = 0.001 和 0.002）和肝硬化患者（P = 0.019 和 0.026）。在校正年龄和性别后，Logistic 回归分析显示 ApaI CC 基因型（比值比：3.02，95%置信区间：1.65-5.51）与 HCC 发展独立相关。
VDR ApaI 多态性在慢性丙型肝炎患者 HCC 的发展中起作用。需要进一步探索这一发现及其意义。
