Liu Ying, Gao Su-jun, Du Bo-xiang, Wang Jie-jun
Department of Oncology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, People's Republic of China.
Tumour Biol. 2014 Apr;35(4):3551-61. doi: 10.1007/s13277-013-1469-5. Epub 2013 Dec 8.
The associations between IL-6 gene single nucleotide polymorphisms (SNPs) and risk of hepatocellular carcinoma (HCC) are controversial. We performed a meta-analysis to provide more credible evidence. We searched for relevant studies published up to 2013 by performing an efficient searching strategy. Odds ratios (OR) with 95% confidence interval (95% CI) was used to estimate the strength of the associations between IL-6 polymorphisms and HCC risk. We identified eight case-control studies involving 1,448 HCC cases and 3,160 controls. Our estimation specifically focused on two SNPs of the IL-6 gene, -174 G/C and -572 G/C. The combined results showed that association between IL-6-174 G/C polymorphism and risk of HCC was significant under additive model (CC vs. GG: OR 0.36; 95% CI, 0.16, 0.85) and recessive model (GG+CG vs. CC: OR 2.82; 95% CI 1.26, 6.28). However, the IL-6-572 G/C polymorphism was not associated with HCC risk. In conclusion, IL-6-174 G/C, but not -572 G/C polymorphism could be a candidate for susceptibility to HCC. However, the results should be cautiously interpreted due to the limited number of the included studies.
白细胞介素-6（IL-6）基因单核苷酸多态性（SNP）与肝细胞癌（HCC）风险之间的关联存在争议。我们进行了一项荟萃分析以提供更可靠的证据。我们通过高效的检索策略检索了截至2013年发表的相关研究。采用比值比（OR）及其95%置信区间（95%CI）来估计IL-6基因多态性与HCC风险之间关联的强度。我们纳入了八项病例对照研究，共涉及1448例HCC病例和3160例对照。我们的评估特别聚焦于IL-6基因的两个SNP，即-174 G/C和-572 G/C。合并结果显示，在加性模型下（CC与GG比较：OR 0.36；95%CI为0.16，0.85）以及隐性模型下（GG + CG与CC比较：OR 2.82；95%CI为1.26，6.28），IL-6 -174 G/C多态性与HCC风险之间的关联具有统计学意义。然而，IL-6 -572 G/C多态性与HCC风险无关。总之，IL-6 -174 G/C多态性而非-572 G/C多态性可能是HCC易感性的一个候选因素。然而，由于纳入研究数量有限，对结果应谨慎解读。
