Wu Xu, Hu Wei, Lu Lan, Zhao Yueshui, Zhou Yejiang, Xiao Zhangang, Zhang Lin, Zhang Hanyu, Li Xiaobing, Li Wanping, Wang Shengpeng, Cho Chi Hin, Shen Jing, Li Mingxing
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, China.
Acta Pharm Sin B. 2019 Mar;9(2):203-219. doi: 10.1016/j.apsb.2018.09.002. Epub 2018 Sep 6.
Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components. Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, we summarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent.
肿瘤细胞连同小部分癌症干细胞存在于由脉管系统、癌症相关成纤维细胞、免疫细胞和细胞外成分组成的基质微环境中。最近的流行病学和临床研究有力地支持补充维生素D与降低癌症风险和良好预后相关。实验结果表明，维生素D不仅能抑制癌细胞，还能调节肿瘤微环境以促进肿瘤抑制。在这篇综述中，我们概述了目前关于维生素D的流行病学研究和临床试验的知识。值得注意的是，我们总结并讨论了维生素D在肿瘤微环境中的癌细胞、癌症干细胞和基质细胞中的抗癌作用，以便更好地理解维生素D在癌症中的作用。我们目前重新提出维生素D是一种新型且经济的抗癌剂。
