Dong Song, Liu Yueling, Chen Jieping
Department of Hematology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Chongqing, 400038, China.
Tumour Biol. 2014 Sep;35(9):8913-9. doi: 10.1007/s13277-014-2082-y. Epub 2014 Jun 4.
An increasing body of evidence has shown that the amino acid changes at position 1298 might eliminate methylenetetrahydrofolate reductase (MTHFR) enzyme activity, leading to insufficient folic acid and subsequent human chromosome breakage. Epidemiological studies have linked MTHFR single-nucleotide polymorphism (SNP) rs1801131 to myeloid leukemia risk, with considerable discrepancy in their results. We therefore were prompted to clarify this issue by use of a meta-analysis. The search terms were used to cover the possible reports in the MEDLINE, Web of Knowledge, and China National Knowledge Infrastructure (CNKI) databases. Odds ratios were estimated to assess the association of SNP rs1801131 with myeloid leukemia risk. Statistical heterogeneity was detected using the Q-statistic and I (2) metric. Subgroup analysis was performed by ethnicity, histological subtype, and Hardy-Weinberg equilibrium (HWE). This meta-analysis of eight publications with a total of 1,114 cases and 3,227 controls revealed no global association. Nor did the subgroup analysis according to histological subtype and HWE show any significant associations. However, Asian individuals who harbored the CC genotype were found to have 1.66-fold higher risk of myeloid leukemia (odds ratio, 1.66; 95 % confidence interval, 1.10 to 2.49; P h = 0.342; I (2) = 0.114). Our meta-analysis has presented evidence supporting a possible association between the CC genotype of MTHFR SNP rs1801131 and myeloid leukemia in Asian populations.
越来越多的证据表明，1298位的氨基酸变化可能会消除亚甲基四氢叶酸还原酶（MTHFR）的酶活性，导致叶酸不足并随后引发人类染色体断裂。流行病学研究已将MTHFR单核苷酸多态性（SNP）rs1801131与髓系白血病风险联系起来，但其结果存在相当大的差异。因此，我们通过荟萃分析来澄清这个问题。搜索词用于涵盖MEDLINE、Web of Knowledge和中国知网（CNKI）数据库中的可能报告。估计比值比以评估SNP rs1801131与髓系白血病风险的关联。使用Q统计量和I²指标检测统计异质性。按种族、组织学亚型和哈迪-温伯格平衡（HWE）进行亚组分析。对8篇共1114例病例和3227例对照的出版物进行的这项荟萃分析显示没有总体关联。根据组织学亚型和HWE进行的亚组分析也未显示任何显著关联。然而，发现携带CC基因型的亚洲个体患髓系白血病的风险高1.66倍（比值比，1.66；95%置信区间，1.10至2.49；P h = 0.342；I² = 0.114）。我们的荟萃分析提供了证据，支持MTHFR SNP rs1801131的CC基因型与亚洲人群髓系白血病之间可能存在关联。
