Liu Long, Yang Zhihui, Zhang Weixing, Yan Bing, Gu Qunhao, Jiao Jianpeng, Yue Xiaoqiang
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China.
Tumour Biol. 2014 Sep;35(9):8875-81. doi: 10.1007/s13277-014-2160-1. Epub 2014 Jun 4.
Increasing evidence indicated that insulin-like growth factor binding protein 7 (IGFBP7) was regarded as a potential tumor suppressor in various human cancers, but its role in gastric cancer is still largely unknown. In the present study, we performed a retrospective study which includes 247 gastric cancer patients. Among them, the IGFBP7 expression was detected by qRT-PCR in 138 cases of gastric cancer and adjacent non-tumor tissues and was further correlated with the expression of p53, Ki-67, and the clinicopathologic features. The results indicated that both IGFBP7 mRNA and protein in gastric cancer tissues were significantly lower than those in the adjacent non-tumor tissues. Additionally, the expression of IGFBP7 was correlated with the depth of invasion, lymph node metastasis, and TNM stage. Interestingly, the expression of IGFBP7 was negatively associated with Ki-67 (r = -0.227, P < 0.001) but positively associated with p53 (r = 0.140, P = 0.028). Univariate analysis showed that low expression of IGFBP7 was associated with poor prognosis (P < 0.001), and multivariate analysis showed that IGFBP7 (HR = 1.87; 95 % CI 1.65-2.17), distant metastasis (HR = 2.68; 95 % CI 1.58-4.56), and tumor size (HR = 1.45; 95 % CI 0.90-2.32) were independent prognostic factors for gastric cancer patients. These results demonstrated that IGFBP7 was downregulated in gastric cancer, and its low expression was potentially correlated with increased cancer cell proliferation and could be used to predicate poor prognosis in these patients.
越来越多的证据表明，胰岛素样生长因子结合蛋白7（IGFBP7）在多种人类癌症中被视为一种潜在的肿瘤抑制因子，但其在胃癌中的作用仍 largely未知。在本研究中，我们进行了一项回顾性研究，纳入了247例胃癌患者。其中，通过qRT-PCR检测了138例胃癌及癌旁非肿瘤组织中的IGFBP7表达，并进一步将其与p53、Ki-67的表达及临床病理特征相关联。结果表明，胃癌组织中的IGFBP7 mRNA和蛋白均显著低于癌旁非肿瘤组织。此外，IGFBP7的表达与浸润深度、淋巴结转移及TNM分期相关。有趣的是，IGFBP7的表达与Ki-67呈负相关（r = -0.227，P < 0.001），但与p53呈正相关（r = 0.140，P = 0.028）。单因素分析显示，IGFBP7低表达与预后不良相关（P < 0.001），多因素分析显示，IGFBP7（HR = 1.87；95%CI 1.65 - 2.17）、远处转移（HR = 2.68；95%CI 1.58 - 4.56）和肿瘤大小（HR = 1.45；95%CI 0.90 - 2.32）是胃癌患者的独立预后因素。这些结果表明，IGFBP7在胃癌中表达下调，其低表达可能与癌细胞增殖增加相关，并可用于预测这些患者的不良预后。
