Celik Cihan, Tokgöz Ozlem, Serifoğlu Lsmail, Tor Meltem, Alpay Atilla, Erdem Zuhal
Department of Radiology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
Department of Radiology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey
Ultrason Imaging. 2014 Jul;36(3):177-186. doi: 10.1177/0161734613514391. Epub 2014 Jun 3.
The aim of this study was to evaluate the hemodynamic changes in the extraocular orbital vessels of the patients with chronic obstructive pulmonary disease (COPD), using color Doppler ultrasonography, and to compare the results with those of healthy control subjects. The control group consisted of 35 healthy subjects who had no systemic problems, while the study group consisted of 60 patients with the diagnosis of COPD. Patients with COPD were grouped according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Twenty patients of stage 1 COPD (mild airflow limitation), stage 2 COPD (moderate airflow limitation), or stage 3 COPD (severe airflow limitation) were included in the groups 1, 2, and 3, respectively. Measurements were performed in both eyes of each participant. Peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI), and pulsatility index (PI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary artery (PCA). The RI and PI measurements of the OA, CRA, and PCA were significantly higher in group 3 when compared to the control group and groups 1 and 2. These significances were not observed when PSV and EDV values were compared. There were also no significant differences between groups 1, 2, and control patients, when mean PSV, EDV, RI, and PI values of all arteries were compared. None of the above parameters showed statistical significance when mean RI, PI, PSV, and EDV were compared between left and right eyes. Severe (stage 3) COPD is associated with impaired retrobulbar hemodynamics. Increased hypoxia and vascular mediators may be suggested in etiology.
本研究旨在运用彩色多普勒超声评估慢性阻塞性肺疾病（COPD）患者眼外眶血管的血流动力学变化，并将结果与健康对照者进行比较。对照组由35名无全身问题的健康受试者组成，而研究组由60名诊断为COPD的患者组成。COPD患者根据慢性阻塞性肺疾病全球倡议（GOLD）进行分组。1期COPD（轻度气流受限）、2期COPD（中度气流受限）或3期COPD（重度气流受限）的20名患者分别纳入第1组、第2组和第3组。对每位参与者的双眼进行测量。测量眼动脉（OA）、视网膜中央动脉（CRA）和睫状后动脉（PCA）的收缩期峰值流速（PSV）、舒张末期流速（EDV）、阻力指数（RI）和搏动指数（PI）。与对照组以及第1组和第2组相比，第3组中OA、CRA和PCA的RI和PI测量值显著更高。比较PSV和EDV值时未观察到这些显著差异。比较所有动脉的平均PSV、EDV、RI和PI值时，第1组、第2组和对照组患者之间也无显著差异。比较左右眼的平均RI、PI、PSV和EDV时，上述参数均未显示出统计学意义。重度（3期）COPD与球后血流动力学受损有关。病因可能提示缺氧增加和血管介质增多。
