Botsa Evanthia, Poulou Loukia S, Koutsogiannis Ioannis, Ziakas Panayiotis D, Koundouraki Antonia, Alexopoulou Efthimia, Thanos Loukas
First Pediatric Clinic, Agia Sofia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Pediatr Radiol. 2014 Nov;44(11):1421-5. doi: 10.1007/s00247-014-3008-y. Epub 2014 Jun 4.
Image-guided radiofrequency ablation is a well-accepted technique of interventional oncology in adults.
To evaluate the efficacy and safety of CT-guided radiofrequency ablation as a minimally invasive treatment for metastatic neoplasms in children.
A total of 15 radiofrequency ablation sessions were performed in 12 children and young adults (median age 9.5; range 5-18 years) with metastatic malignancies. Seven children and young adults had secondary hepatic lesions, three had pulmonary and two had bone lesions. Radiofrequency ablation was performed under conscious sedation.
The median lesion size was 1.7 cm (range 1.3-2.8 cm). The median time for ablation was 8 min (range 7-10 min). Radiofrequency procedures were technically successful in all tumors. Postablation imaging immediately after, and 1 month and 3 months after radiofrequency ablation showed total necrosis in all patients. At 6-month follow-up, three patients (all with lesion size >2 cm) had local recurrence and underwent a second radiofrequency ablation session. At 2-year follow-up no patient had recurrence of the treated tumor. Post-ablation syndrome occurred in four children. No major complication occurred.
CT-guided radiofrequency tumor ablation was safe and efficient for palliative treatment in our cohort of patients.
图像引导下的射频消融是成人介入肿瘤学中一种被广泛接受的技术。
评估CT引导下射频消融作为儿童转移性肿瘤微创治疗的有效性和安全性。
对12例患有转移性恶性肿瘤的儿童和青年（中位年龄9.5岁；范围5 - 18岁）进行了总共15次射频消融治疗。7例儿童和青年有继发性肝病变，3例有肺部病变，2例有骨病变。射频消融在清醒镇静下进行。
病变的中位大小为1.7厘米（范围1.3 - 2.8厘米）。消融的中位时间为8分钟（范围7 - 10分钟）。射频手术在所有肿瘤中技术上均获成功。射频消融后即刻、1个月和3个月后的消融后成像显示所有患者均出现完全坏死。在6个月随访时，3例患者（均病变大小>2厘米）出现局部复发并接受了第二次射频消融治疗。在2年随访时，无患者出现所治疗肿瘤的复发。4例儿童出现了消融后综合征。未发生重大并发症。
在我们的患者队列中，CT引导下的射频肿瘤消融对于姑息治疗是安全且有效的。
