Li Si-ming, Wang Wen-fei, Zhou Li-hong, Ma Lei, An Ying, Xu Wen-juan, Li Tian-he, Yu Yin-hang, Li De-shan, Liu Yan
School of Life Science, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin, 150030, China.
Endocrine. 2015 Mar;48(2):519-27. doi: 10.1007/s12020-014-0309-8. Epub 2014 Jun 4.
Fibroblast growth factor 21 (FGF21), a recently discovered regulatory factor, plays an important role in glucose and lipid metabolism. In this study, we firstly found the FGF21 expression in white blood cells (WBCs). Then, we enrolled 51 women with gestational diabetes mellitus (GDM) and 50 pregnant women with normal blood glucose levels to determine the FGF21 levels in the WBCs and the sera at the 28th week of pregnancy, and tracked the dynamic changes of FGF21 in these women until the 7th day postpartum. Repeated Measures analysis of variance (ANOVA) revealed that there was a significant interaction effect between group and time on FGF21 levels (P < 0.05). FGF21 levels were significantly higher in the GDM patients than those in the controls at the 28th week of pregnancy. The 7th day after the delivery, the FGF21 levels decreased in the WBCs and the sera in both groups. The D values (the difference between pregnancy and postpartum) for FGF21 levels were significantly higher in the GDM group (P < 0.05). Serum FGF21 level during gestation positively correlated with leptin, triglyceride, and HDL-cholesterol, and FGF21 may act as a glucose and lipid metabolism compensatory regulatory factor to improve glucose and lipid metabolism during the period of pregnancy. Further, FGF21 level in the WBCs (during pregnancy and the D values for FGF21) was chiefly influenced by GDM.
成纤维细胞生长因子21（FGF21）是一种最近发现的调节因子，在葡萄糖和脂质代谢中发挥重要作用。在本研究中，我们首先发现了白细胞（WBCs）中FGF21的表达。然后，我们招募了51名妊娠期糖尿病（GDM）女性和50名血糖水平正常的孕妇，以测定妊娠第28周时白细胞和血清中的FGF21水平，并追踪这些女性中FGF21的动态变化直至产后第7天。重复测量方差分析（ANOVA）显示，组和时间对FGF21水平有显著的交互作用（P < 0.05）。妊娠第28周时，GDM患者的FGF21水平显著高于对照组。分娩后第7天，两组白细胞和血清中的FGF21水平均下降。GDM组FGF21水平的D值（妊娠与产后的差异）显著更高（P < 0.05）。妊娠期血清FGF21水平与瘦素、甘油三酯和高密度脂蛋白胆固醇呈正相关，FGF21可能作为一种葡萄糖和脂质代谢的代偿调节因子，在孕期改善葡萄糖和脂质代谢。此外，白细胞中的FGF21水平（孕期及FGF21的D值）主要受GDM影响。
