Fortunato Francesca, Martinelli Domenico, Prato Rosa, Pedalino Biagio
Department of Medical and Surgical Sciences, University of Foggia, 71121 Foggia, Italy.
ScientificWorldJournal. 2014;2014:614269. doi: 10.1155/2014/614269. Epub 2014 May 7.
Celiac disease (CD) is a chronic autoimmune illness triggered by gluten consumption in genetically predisposed individuals. Worldwide, CD prevalence is approximately 1%. Several studies suggest a higher prevalence of undiagnosed CD in patients with infertility. We described reproductive disorders and assessed the frequency of hospital admissions for infertility among celiac women aged 15-49. We conducted two surveys enrolling a convenient sample of celiac women, residing in Apulia or in Basilicata (Italy). Moreover, we selected hospital discharge records (HDRs) of celiac women and women with an exemption for CD, and matched the lists with HDRs for reproductive disorders. In the surveys we included 91 celiac women; 61.5% of them reported menstrual cycle disorders. 47/91 reported at least one pregnancy and 70.2% of them reported problems during pregnancy. From the HDRs and the registry of exemption, we selected 4,070 women with CD; the proportion of women hospitalized for infertility was higher among celiac women than among resident women in childbearing age (1.2% versus 0.2%). Our findings highlight a higher prevalence of reproductive disorders among celiac women than in the general population suggesting that clinicians might consider testing for CD women presenting with pregnancy disorders or infertility.
乳糜泻（CD）是一种慢性自身免疫性疾病，由具有遗传易感性的个体摄入麸质引发。在全球范围内，乳糜泻的患病率约为1%。多项研究表明，不孕症患者中未确诊的乳糜泻患病率更高。我们描述了生殖系统疾病，并评估了15至49岁乳糜泻女性因不孕症住院的频率。我们进行了两项调查，纳入了居住在普利亚或巴西利卡塔（意大利）的乳糜泻女性的便利样本。此外，我们选取了乳糜泻女性和免除乳糜泻诊断的女性的医院出院记录（HDR），并将这些列表与生殖系统疾病的HDR进行匹配。在调查中，我们纳入了91名乳糜泻女性；其中61.5%报告有月经周期紊乱。47/91报告至少有过一次怀孕，其中70.2%报告在怀孕期间有问题。从HDR和免除诊断登记册中，我们选取了4070名患有乳糜泻的女性；乳糜泻女性中因不孕症住院的比例高于育龄期常住女性（1.2%对0.2%）。我们的研究结果表明，乳糜泻女性中生殖系统疾病的患病率高于一般人群，这表明临床医生可能应考虑对出现妊娠疾病或不孕症的女性进行乳糜泻检测。
