The Celiac Disease Center at Columbia University, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Therap Adv Gastroenterol. 2012 Jan;5(1):37-47. doi: 10.1177/1756283X11417038.
The prevalence of celiac disease is rising. As a result there is increasing interest in the associated mortality and morbidity of the disease. Screening of asymptomatic individuals in the general population is not currently recommended; instead, a strategy of case finding is the preferred approach, taking into account the myriad modes of presentation of celiac disease. Although a gluten-free diet is the treatment of choice in symptomatic patients with celiac disease, there is no consensus on whether institution of a gluten-free diet will improve the quality of life in asymptomatic screen-detected celiac disease patients. A review of the studies that have been performed on this subject is presented. Certain patient groups such as those with autoimmune diseases may be offered screening in the context of an informed discussion regarding the potential benefits, with the caveat that the data on this issue are sparse. Active case finding seems to be the most prudent option in most clinical situations.
乳糜泻的患病率正在上升。因此，人们越来越关注该病的相关死亡率和发病率。目前不建议对普通人群中的无症状个体进行筛查；相反，考虑到乳糜泻的多种表现形式，采用病例发现策略是首选方法。虽然无麸质饮食是乳糜泻患者的首选治疗方法，但对于无症状筛查发现的乳糜泻患者，是否采用无麸质饮食是否会提高生活质量尚无共识。本文对这方面的研究进行了综述。某些患者群体，如自身免疫性疾病患者，可能会在知情讨论的情况下接受筛查，讨论潜在的益处，但关于这个问题的数据还很有限。在大多数临床情况下，主动病例发现似乎是最谨慎的选择。
