[Pathogenesis and clinical aspects of AIDS].

Infection by Human Immunodeficiency Virus (HIV) is the recognized cause of the Acquired Immunodeficiency Syndrome (AIDS) and related syndromes, all characterized by a devastating and progressive impairment of immunity. What ensues is the onset of opportunistic infections, neoplasms, both central and peripheral nervous system alterations and other conditions as well. Current therapeutic options, either with antiretroviral and anti-infective drugs, are only credited to prolong survival while not assuring definite cure. A significant improvement in the clinical management of these patients could be anticipated only after a better understanding of HIV life-cycle and its pathogenetic mechanisms.