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Probing the average local structure of biomolecules using small-angle scattering and scaling laws.利用小角散射和标度律探测生物分子的平均局部结构。
Biophys J. 2014 Jun 3;106(11):2474-82. doi: 10.1016/j.bpj.2014.03.050.
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A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins.柔性和内在无序蛋白质的小角X射线散射（SAXS）实用指南。
FEBS Lett. 2015 Sep 14;589(19 Pt A):2570-7. doi: 10.1016/j.febslet.2015.08.027. Epub 2015 Aug 29.
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Structural Analyses of Intrinsically Disordered Proteins by Small-Angle X-Ray Scattering.小角 X 射线散射法分析无规卷曲蛋白的结构。
Methods Mol Biol. 2020;2141:249-269. doi: 10.1007/978-1-0716-0524-0_12.
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Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water.创新的散射分析表明，疏水无序蛋白在水中会膨胀。
Science. 2017 Oct 13;358(6360):238-241. doi: 10.1126/science.aan5774.
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An Extended Guinier Analysis for Intrinsically Disordered Proteins.用于无序蛋白质的扩展 Guinier 分析。
J Mol Biol. 2018 Aug 3;430(16):2540-2553. doi: 10.1016/j.jmb.2018.03.007. Epub 2018 Mar 21.
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Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering.小角散射研究高弹性蛋白的结构特征。
Adv Exp Med Biol. 2017;1009:107-129. doi: 10.1007/978-981-10-6038-0_7.
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Computing, Analyzing, and Comparing the Radius of Gyration and Hydrodynamic Radius in Conformational Ensembles of Intrinsically Disordered Proteins.计算、分析和比较构象集合中固有无序蛋白质的回转半径和流体力学半径。
Methods Mol Biol. 2020;2141:429-445. doi: 10.1007/978-1-0716-0524-0_21.
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Small-angle scattering studies of intrinsically disordered proteins and their complexes.内在无序蛋白质及其复合物的小角散射研究。
Curr Opin Struct Biol. 2017 Feb;42:15-23. doi: 10.1016/j.sbi.2016.10.011. Epub 2016 Oct 26.
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Dimension conversion and scaling of disordered protein chains.无序蛋白质链的尺寸转换与缩放
Mol Biosyst. 2016 Aug 16;12(9):2932-40. doi: 10.1039/c6mb00415f.
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On the Calculation of SAXS Profiles of Folded and Intrinsically Disordered Proteins from Computer Simulations.折叠和固有无序蛋白质的小角 X 射线散射（SAXS）曲线的从计算机模拟中的计算。
J Mol Biol. 2018 Aug 3;430(16):2521-2539. doi: 10.1016/j.jmb.2018.03.002. Epub 2018 Mar 14.
引用本文的文献
1
The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau.与全长tau相比，疾病相关的tau35片段具有更高的聚集倾向。
Front Mol Biosci. 2021 Oct 28;8:779240. doi: 10.3389/fmolb.2021.779240. eCollection 2021.
2
Methods, development and applications of small-angle X-ray scattering to characterize biological macromolecules in solution.用于表征溶液中生物大分子的小角X射线散射的方法、发展及应用。
Curr Res Struct Biol. 2020 Aug 27;2:164-170. doi: 10.1016/j.crstbi.2020.08.004. eCollection 2020.
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Water as a Good Solvent for Unfolded Proteins: Folding and Collapse are Fundamentally Different.水是展开蛋白质的良好溶剂：折叠和坍塌从根本上是不同的。
J Mol Biol. 2020 Apr 17;432(9):2882-2889. doi: 10.1016/j.jmb.2020.01.031. Epub 2020 Feb 7.
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Commonly used FRET fluorophores promote collapse of an otherwise disordered protein.常用的 FRET 荧光团会促使原本无序的蛋白质发生崩溃。
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8889-8894. doi: 10.1073/pnas.1813038116. Epub 2019 Apr 16.
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Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein.β-突触核蛋白通过多效相互作用抑制α-突触核蛋白聚集。
J Mol Biol. 2018 Aug 3;430(16):2360-2371. doi: 10.1016/j.jmb.2018.05.024. Epub 2018 May 18.
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Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements.杂多序列中大小和形状波动的解耦调和了 SAXS 与 FRET 测量之间的差异。
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6342-E6351. doi: 10.1073/pnas.1704692114. Epub 2017 Jul 17.
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Quarterly intrinsic disorder digest (April-May-June, 2014).季度内在无序摘要（2014年4月 - 5月 - 6月）
Intrinsically Disord Proteins. 2017 Mar 1;5(1):e1287505. doi: 10.1080/21690707.2017.1287505. eCollection 2017.
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Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments.为成功的生物小角 X 射线和中子散射实验制备单分散大分子样品。
Nat Protoc. 2016 Nov;11(11):2122-2153. doi: 10.1038/nprot.2016.113. Epub 2016 Oct 6.
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The PTEN Tumor Suppressor Forms Homodimers in Solution.PTEN肿瘤抑制因子在溶液中形成同源二聚体。
Structure. 2015 Oct 6;23(10):1952-1957. doi: 10.1016/j.str.2015.07.012. Epub 2015 Aug 20.
本文引用的文献
1
Small-angle neutron scattering study of a monoclonal antibody using free-energy constraints.利用自由能约束进行单克隆抗体的小角中子散射研究。
J Phys Chem B. 2013 Nov 14;117(45):14029-38. doi: 10.1021/jp408710r. Epub 2013 Oct 31.
2
Accurate assessment of mass, models and resolution by small-angle scattering.小角散射法评估质量、模型和分辨率。
Nature. 2013 Apr 25;496(7446):477-81. doi: 10.1038/nature12070.
3
Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy.用单分子光谱法定量研究展开和无规卷曲蛋白质的聚合物标度律。
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16155-60. doi: 10.1073/pnas.1207719109. Epub 2012 Sep 14.
4
Integrative structural modeling with small angle X-ray scattering profiles.基于小角X射线散射图谱的整合结构建模
BMC Struct Biol. 2012 Jul 16;12:17. doi: 10.1186/1472-6807-12-17.
5
How random are intrinsically disordered proteins? A small angle scattering perspective.固有无序蛋白的随机性如何？小角散射视角。
Curr Protein Pept Sci. 2012 Feb;13(1):55-75. doi: 10.2174/138920312799277901.
6
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering.利用小角X射线散射对内在无序蛋白质进行结构分析。
Mol Biosyst. 2012 Jan;8(1):151-67. doi: 10.1039/c1mb05275f. Epub 2011 Sep 22.
7
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.运用 Porod-Debye 定律，通过小角散射（SAS）对灵活的、固有无规的生物大分子进行特征描述。
Biopolymers. 2011 Aug;95(8):559-71. doi: 10.1002/bip.21638. Epub 2011 Apr 20.
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Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes.MeCP2-核小体复合物的生物物理分析和小角 X 射线散射结构。
Nucleic Acids Res. 2011 May;39(10):4122-35. doi: 10.1093/nar/gkr005. Epub 2011 Jan 29.
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The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices.水疱性口炎病毒磷酸蛋白的 N(0)-结合区整体呈无规卷曲，但含有瞬态α-螺旋。
Protein Sci. 2011 Mar;20(3):542-56. doi: 10.1002/pro.587. Epub 2011 Feb 16.
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A series of PDB related databases for everyday needs.一系列满足日常需求的与蛋白质数据银行（PDB）相关的数据库。
Nucleic Acids Res. 2011 Jan;39(Database issue):D411-9. doi: 10.1093/nar/gkq1105. Epub 2010 Nov 11.
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