Covarrubias Anthony J, Horng Tiffany
Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Cell Metab. 2014 Jun 3;19(6):898-9. doi: 10.1016/j.cmet.2014.05.009.
Interleukin-6 (IL-6) is a pleiotropic cytokine that exerts either proinflammatory or anti-inflammatory effects and is implicated in diverse settings, including obesity, exercise, arthritis, and colitis. A new study shows that modulation of macrophage activation by IL-6 maintains glucose homeostasis in diet-induced obesity while limiting inflammation in endotoxemia (Mauer et al., 2014).
白细胞介素-6(IL-6)是一种多效性细胞因子,具有促炎或抗炎作用,涉及多种情况,包括肥胖、运动、关节炎和结肠炎。一项新研究表明,IL-6对巨噬细胞激活的调节在饮食诱导的肥胖中维持葡萄糖稳态,同时限制内毒素血症中的炎症(Mauer等人,2014年)。