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本文引用的文献

1
Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice.白细胞介素-6 有助于小鼠早期禁食诱导的游离脂肪酸动员。
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 1;306(11):R861-7. doi: 10.1152/ajpregu.00533.2013. Epub 2014 Apr 2.
2
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.IL-6 信号促进巨噬细胞的替代性激活，以限制内毒素血症和肥胖相关的胰岛素抵抗。
Nat Immunol. 2014 May;15(5):423-30. doi: 10.1038/ni.2865. Epub 2014 Mar 30.
3
Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.骨骼肌与免疫细胞间的串扰：肌源介质及其代谢意义。
Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E453-65. doi: 10.1152/ajpendo.00553.2012. Epub 2012 Dec 31.
4
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. alternatively 激活的巨噬细胞产生儿茶酚胺以维持适应性生热。
Nature. 2011 Nov 20;480(7375):104-8. doi: 10.1038/nature10653.
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Macrophage-mediated inflammation in metabolic disease.巨噬细胞介导体内炎症与代谢疾病。
Nat Rev Immunol. 2011 Oct 10;11(11):738-49. doi: 10.1038/nri3071.
6
The pro- and anti-inflammatory properties of the cytokine interleukin-6.细胞因子白细胞介素-6的促炎和抗炎特性。
Biochim Biophys Acta. 2011 May;1813(5):878-88. doi: 10.1016/j.bbamcr.2011.01.034. Epub 2011 Feb 4.
7
Inflammatory mechanisms in obesity.肥胖中的炎症机制。
Annu Rev Immunol. 2011;29:415-45. doi: 10.1146/annurev-immunol-031210-101322.
8
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue.体重减轻和脂肪分解促进了小鼠脂肪组织中的动态免疫反应。
J Clin Invest. 2010 Oct;120(10):3466-79. doi: 10.1172/JCI42845. Epub 2010 Sep 27.
9
Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis.观点：白细胞介素-6在胰岛素敏感性和葡萄糖稳态中确实具有有益作用。
J Appl Physiol (1985). 2007 Feb;102(2):814-6. doi: 10.1152/japplphysiol.01208.2006. Epub 2006 Oct 26.
10
Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice.白细胞介素-6缺陷小鼠应激和寒冷诱导的能量消耗增加减少。
Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R551-7. doi: 10.1152/ajpregu.00514.2005.

白细胞介素-6在代谢性炎症中取得平衡。

IL-6 strikes a balance in metabolic inflammation.

作者信息

Covarrubias Anthony J, Horng Tiffany

机构信息

Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

出版信息

Cell Metab. 2014 Jun 3;19(6):898-9. doi: 10.1016/j.cmet.2014.05.009.

DOI:10.1016/j.cmet.2014.05.009
PMID:24896536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4103792/
Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine that exerts either proinflammatory or anti-inflammatory effects and is implicated in diverse settings, including obesity, exercise, arthritis, and colitis. A new study shows that modulation of macrophage activation by IL-6 maintains glucose homeostasis in diet-induced obesity while limiting inflammation in endotoxemia (Mauer et al., 2014).

摘要

白细胞介素-6（IL-6）是一种多效性细胞因子，具有促炎或抗炎作用，涉及多种情况，包括肥胖、运动、关节炎和结肠炎。一项新研究表明，IL-6对巨噬细胞激活的调节在饮食诱导的肥胖中维持葡萄糖稳态，同时限制内毒素血症中的炎症（Mauer等人，2014年）。