Weissferdt Annikka, Moran Cesar A
Department of Pathology, MD Anderson Cancer Center, Houston, TX.
Appl Immunohistochem Mol Morphol. 2014 Aug;22(7):479-87. doi: 10.1097/PAI.0b013e3182a53856.
The diagnosis of thymic epithelial neoplasms is normally rendered after careful evaluation of their histologic features. In some cases, however, the morphological heterogeneity or overlap with neoplasms of other organ systems can lead to diagnostic uncertainty. On the basis of this, the use of immunohistochemical stains as a diagnostic adjunct has become a popular tool. Although undoubtedly, immunohistochemistry has its role in the diagnosis of difficult cases, to date there are no specific markers that would distinguish thymic epithelial neoplasms from other tumors and interpretation of immunohistochemical results should only ever be made in conjunction with accurate morphologic analysis and careful clinical evaluation. This article will review the current knowledge of the immunohistochemical phenotype of thymic epithelial neoplasms with particular emphasis on its use for diagnostic purposes and the latest advances in this field.
胸腺上皮性肿瘤的诊断通常是在仔细评估其组织学特征后做出的。然而，在某些情况下，其形态学异质性或与其他器官系统肿瘤的重叠可能导致诊断的不确定性。基于此，使用免疫组织化学染色作为诊断辅助手段已成为一种常用工具。虽然毫无疑问，免疫组织化学在疑难病例的诊断中发挥着作用，但迄今为止，尚无能够将胸腺上皮性肿瘤与其他肿瘤区分开来的特异性标志物，免疫组织化学结果的解读应始终结合准确的形态学分析和仔细的临床评估。本文将综述胸腺上皮性肿瘤免疫组织化学表型的当前知识，特别强调其在诊断中的应用以及该领域的最新进展。
