Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil.
Pharmacogenomics. 2014 Apr;15(6):775-84. doi: 10.2217/pgs.14.30.
Sildenafil potentiates the nitric oxide (NO) signaling pathway. Since neuronal NOS is very important in the penis, we assessed whether NOS1 polymorphisms are associated with altered responsiveness to sildenafil in erectile dysfunction (ED).
MATERIALS & METHODS: Patients (n = 137) were divided as clinical ED or postoperative ED. They were subdivided as good responders or poor responders to sildenafil, and genotypes for rs41279104 and rs2682826 NOS1 polymorphisms were determined.
We found that the rs41279104 CT genotype was associated with good responders in postoperative ED patients, while rs2682826 CT genotype was associated with good responders in postoperative ED, and the TT genotype associated with good responders in both groups. Finally, the CT haplotype was associated with good responders in postoperative ED.
NOS1 polymorphisms are associated with responsiveness to sildenafil in ED. Original submitted 20 November 2013; Revision submitted 31 January 2014.
西地那非增强一氧化氮（NO）信号通路。由于神经元型一氧化氮合酶（nNOS）在阴茎中非常重要，我们评估了 NOS1 多态性是否与勃起功能障碍（ED）患者对西地那非反应性的改变有关。
将患者（n=137）分为临床 ED 或术后 ED。根据对西地那非的反应将其分为良好反应者和不良反应者，并确定 NOS1 多态性 rs41279104 和 rs2682826 的基因型。
我们发现 rs41279104 的 CT 基因型与术后 ED 患者的良好反应者相关，而 rs2682826 的 CT 基因型与术后 ED 的良好反应者相关，TT 基因型与两组的良好反应者相关。最后，CT 单倍型与术后 ED 的良好反应者相关。
NOS1 多态性与 ED 患者对西地那非的反应性有关。原始提交日期为 2013 年 11 月 20 日；修订提交日期为 2014 年 1 月 31 日。
