Departamento de Psicobiologia--Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
J Sex Med. 2011 Nov;8(11):3030-9. doi: 10.1111/j.1743-6109.2011.02422.x. Epub 2011 Aug 11.
In recent years, new tools for the study of molecular biology and genetics have resulted in significant contributions to the scientific community. The potential use of genetic variations as biomarkers in the management of current and future conditions is generating considerable excitement in health care for disorders such as erectile dysfunction (ED).
This review briefly describes the molecular and genetic mechanisms involved in ED and provides an overall view of the literature relevant to possible relationships between genetic factors and ED.
This is a narrative review of studies on the potential influence of polymorphisms on the risk of developing ED.
We reviewed genetic association studies involving polymorphisms and the ED phenotype.
There is growing evidence for the influence of genetic polymorphisms on the risk of ED and on the interindividual variability in sildenafil treatment.
Although this field is still in its infancy, genetic association studies aimed at defining a molecular basis for ED have provided some important evidence that a patient's genotype may be used in the future to assess risk, as well as to plan treatment and prevention programs in the clinic.
近年来，分子生物学和遗传学研究的新工具为科学界做出了重大贡献。遗传变异作为当前和未来疾病（如勃起功能障碍（ED））管理的生物标志物的潜在用途，在医疗保健领域引起了相当大的兴奋。
本文简要描述了 ED 涉及的分子和遗传机制，并对遗传因素与 ED 之间可能存在的关系的相关文献进行了全面综述。
这是一篇关于多态性对 ED 发病风险潜在影响的研究的叙述性综述。
我们综述了涉及多态性和 ED 表型的遗传关联研究。
遗传多态性对 ED 风险和西地那非治疗的个体间变异性的影响证据越来越多。
尽管该领域仍处于起步阶段，但旨在确定 ED 分子基础的遗传关联研究提供了一些重要证据，表明患者的基因型可能在未来用于评估风险，以及在临床中规划治疗和预防方案。
