Moura-Grec Patrícia Garcia de, Marsicano Juliane Avansini, Carvalho Cristiane Alves Paz de, Sales-Peres Silvia Helena de Carvalho
Cien Saude Colet. 2014 Jun;19(6):1763-72. doi: 10.1590/1413-81232014196.13482013.
The scope of this study was to conduct a systematic review of the studies on the association between obesity and periodontitis. The methods applied included a literature search strategy and selection of studies using inclusion and exclusion in accordance with the criteria for characteristics of the studies and meta-analysis. The research was conducted in the PubMed, Embase and Lilacs databases through 2010. Selected papers were on studies on humans investigating whether or not obesity is a risk factor for periodontitis. Of the 822 studies identified, 31 studies met the inclusion criteria and were included in this meta-analysis. The risk of periodontitis was associated with obesity (or had a tendency for this) in 25 studies, though it was not associated in 6 studies. The meta-analysis showed a significant association with obesity and periodontitis (OR = 1.30 [95% Confidence Interval (CI), 1.25 - 1.35]) and with mean Body Mass Index (BMI) and periodontal disease (mean difference = 2.75). Obesity was associated with periodontitis, however the risk factors that aggravate these diseases should be better clarified to elucidate the direction of this association. Working with paired samples and avoiding confusion factors may contribute to homogeneity between the studies.
本研究的范围是对肥胖与牙周炎之间关联的研究进行系统综述。所应用的方法包括文献检索策略以及根据研究特征标准和荟萃分析通过纳入和排除来选择研究。该研究在截至2010年的PubMed、Embase和Lilacs数据库中进行。入选论文为关于人类的研究，调查肥胖是否为牙周炎的危险因素。在鉴定出的822项研究中，31项研究符合纳入标准并被纳入该荟萃分析。25项研究中牙周炎风险与肥胖相关（或有此趋势），不过6项研究中两者无关联。荟萃分析显示肥胖与牙周炎之间存在显著关联（比值比=1.30[95%置信区间（CI），1.25 - 1.35]），且平均体重指数（BMI）与牙周疾病之间也存在显著关联（平均差异=2.75）。肥胖与牙周炎相关，然而应更好地阐明加重这些疾病的危险因素，以明确这种关联的方向。使用配对样本并避免混杂因素可能有助于研究之间的同质性。
