Lin Yunfeng, Hamme Ii Ashton T
Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA.
Analyst. 2014 Aug 7;139(15):3702-5. doi: 10.1039/c4an00744a.
Monoclonal antibody-conjugated sphere-shaped gold nanoparticles were combined with single-walled carbon nanotubes (SWCNTs) to create a nanohybrid system to selectively detect and eradicate multiple drug resistant Salmonella (MDRS) typhimurium DT104 bacteria. The Raman signal intensity from Rhodamine 6G (Rh6G) modified monoclonal AC04 antibody SWCNTs-gold nanoparticle (SWCNT-GNPs) hybrid provided a SERS enhancement by several orders of magnitude to detect the MDRS bacteria over the GNP system. A targeted photothermolysis experiment using 670 nm light at 2 W cm(-2) for 15 min, resulted in selective and irreparable damage to more than 99% Salmonella DT104 at the concentration of 10(5) CFU mL(-1). In comparison to solely SWCNTs or GNPs, our SWCNT-GNPs nanohybrids have also shown a better photothermal efficiency.
将单克隆抗体偶联的球形金纳米颗粒与单壁碳纳米管（SWCNTs）相结合，构建了一种纳米杂化系统，用于选择性检测和根除多重耐药鼠伤寒沙门氏菌（MDRS）DT104细菌。罗丹明6G（Rh6G）修饰的单克隆AC04抗体SWCNT-金纳米颗粒（SWCNT-GNPs）杂化物的拉曼信号强度比GNP系统提供了几个数量级的表面增强拉曼散射（SERS）增强，以检测MDRS细菌。使用670 nm光、2 W cm(-2)照射15分钟的靶向光热解实验，在10(5) CFU mL(-1)的浓度下，对超过99%的沙门氏菌DT104造成了选择性且不可修复的损伤。与单独的SWCNTs或GNPs相比，我们的SWCNT-GNPs纳米杂化物也表现出了更好的光热效率。
