Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University).
Psychiatry Clin Neurosci. 2015 Jan;69(1):22-33. doi: 10.1111/pcn.12209. Epub 2014 Jul 29.
Near-infrared spectroscopy has the potential for aiding the diagnosis of major depressive disorder. The purpose of this study was to systematically review the evidence from observational studies regarding the use of near-infrared spectroscopy in patients with major depressive disorder and to identify the characteristic pattern of prefrontal lobe activity in major depressive disorder.
medline, PubMed, Cochrane Library and Web of Science databases were searched in December 2013. All case-control studies were included. The quality of evidence was examined using the Newcastle-Ottawa Quality Assessment Scale. The primary outcome measures were the mean oxygenated and deoxygenated hemoglobin alterations of the cerebral cortex during cognitive activation periods. The standard mean difference for the overall pooled effects across the included studies was estimated using random or fixed effect models. The primary outcome measures were included in the meta-analysis.
Fourteen studies met the inclusion criteria. Six studies (n = 692 participants) were included in the analysis of the mean oxygenated hemoglobin alterations; the pooled mean standardized difference was -0.74 (95% confidence interval, -0.97 to -0.52), indicating that patients with major depressive disorder were associated with attenuated increase in oxygenated hemoglobin during cognitive activation in the prefrontal regions compared to healthy controls. Five studies (n = 668 participants) were included in the analysis of mean deoxygenated-hemoglobin changes; the pooled standardized mean difference was 0.18 (95% confidence interval, -0.20 to 0.56).
Using near-infrared spectroscopy measurements, we observed that compared to healthy subjects, patients with major depressive disorder had significantly lower prefrontal activation during cognitive tasks.
近红外光谱技术有望辅助重度抑郁症的诊断。本研究旨在系统综述观察性研究中关于近红外光谱技术在重度抑郁症患者中的应用证据，并确定重度抑郁症患者前额叶活动的特征模式。
于 2013 年 12 月检索 medline、PubMed、Cochrane 图书馆和 Web of Science 数据库，纳入所有病例对照研究。使用纽卡斯尔-渥太华质量评估量表评估证据质量。主要结局指标为认知激活期大脑皮质氧合和去氧血红蛋白的平均变化。使用随机或固定效应模型估计纳入研究的整体汇总效应的标准化均数差。主要结局指标纳入荟萃分析。
符合纳入标准的研究共有 14 项。其中 6 项研究（n=692 名参与者）纳入氧合血红蛋白平均变化分析，汇总标准化均数差为-0.74（95%置信区间，-0.97 至-0.52），表明与健康对照者相比，重度抑郁症患者在前额区域认知激活时，氧合血红蛋白的增加幅度较低。5 项研究（n=668 名参与者）纳入去氧血红蛋白平均变化分析，汇总标准化均数差为 0.18（95%置信区间，-0.20 至 0.56）。
使用近红外光谱测量，我们观察到与健康受试者相比，重度抑郁症患者在认知任务期间前额叶的激活明显较低。
