Department of Clinical Psychology, Graduate School of Education, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Strand, London, WC2R 2LS, United Kingdom.
Cereb Cortex. 2024 Aug 1;34(8). doi: 10.1093/cercor/bhae321.
Although many neuroimaging studies have evaluated changes in the prefrontal cortex during mindfulness-based interventions, most of these studies were cross-sectional studies of skilled participants or involved pre-post comparisons before and after a single session. While functional near-infrared spectroscopy is a useful tool to capture changes in the hemodynamic response of the prefrontal cortex during continuous mindfulness-based intervention, its ability to detect the accumulated effects of continuous mindfulness-based intervention is currently unclear. We investigated whether a 12-wk online mindfulness-based intervention changed the hemodynamic response of the prefrontal cortex during a verbal fluency task. Eighty-two healthy university students were randomly allocated to a 12-wk online mindfulness-based intervention group or a wait-list control group. The integral values of oxygenated hemoglobin measured using functional near-infrared spectroscopy before and after the intervention were compared to the values in the wait-list group. The intervention condition showed significantly greater functional near-infrared spectroscopy signal activation than the control condition; however, the effect sizes before and after the intervention were small. Thus, continuous mindfulness-based intervention could alter prefrontal cortex function, and functional near-infrared spectroscopy could be useful for measuring the accumulated effects of continuous mindfulness-based interventions. With a better understanding of the association between mindfulness and functional near-infrared spectroscopy signals, functional near-infrared spectroscopy can be used for biofeedback analyses.
虽然许多神经影像学研究已经评估了正念干预过程中前额叶皮层的变化，但这些研究大多是对熟练参与者的横断面研究，或者是在单次干预前后进行的前后比较。虽然功能近红外光谱是一种有用的工具，可以捕捉连续正念干预过程中前额叶皮层血液动力学反应的变化，但它检测连续正念干预累积效应的能力目前尚不清楚。我们研究了 12 周的在线正念干预是否改变了言语流畅性任务期间前额叶皮层的血液动力学反应。82 名健康大学生被随机分配到 12 周的在线正念干预组或候补名单对照组。比较了干预前后使用功能近红外光谱测量的氧合血红蛋白积分值与候补名单组的值。干预条件的功能近红外光谱信号激活明显大于对照条件；然而，干预前后的效应量很小。因此，连续的正念干预可以改变前额叶皮层的功能，功能近红外光谱可以用于测量连续正念干预的累积效应。通过更好地理解正念和功能近红外光谱信号之间的关联，功能近红外光谱可以用于生物反馈分析。
