Wu Qiao, Sun Wei, Liu Jiaojiao, Zhang Peiwen
Department of Psychiatry, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang City, Sichuan Province, People's Republic of China.
Research Center of Educational Neuroscience, School of Educational Science, Huazhong University of Science and Technology, Wuhan City, Hubei Province, People's Republic of China.
Neuropsychiatr Dis Treat. 2024 Dec 19;20:2553-2567. doi: 10.2147/NDT.S499134. eCollection 2024.
Major depressive disorder (MDD) poses a significant treatment challenge, with some patients unresponsive to conventional therapies. Electroconvulsive therapy (ECT) can be effective but its mechanisms are not fully understood. This study employs functional Near-Infrared Spectroscopy (fNIRS) to explore the neurobiological changes induced by ECT in A MDD patient, aiming to shed light on its therapeutic effects.
This study employs fNIRS to assess differences between MDD patient and controls, and examines changes in cerebral hemodynamics and brain network nodes post-ECT to elucidate treatment mechanisms.
26 age and gender-matched controls and one MDD male patient underwent fNIRS during a verbal fluency task. The patient received ECT, with dynamic evaluation of beta, integral, and centroid values in regions of interest (ROIs) post-treatment. Resting-state fNIRS and functional connectivity assessments were also conducted post-ECT.
MDD patient exhibited significantly lower hemodynamic metrics and functional connectivity compared to controls at baseline. Post-ECT, dynamic changes in these metrics were observed, trending towards normalization and showing no significant differences from controls.
ECT modifies cerebral hemodynamics and functional connectivity in depressive patients, as evidenced by fNIRS metrics. This study underscores the utility of fNIRS for objective neurobiological monitoring in ECT treatment.
重度抑郁症（MDD）带来了重大的治疗挑战，一些患者对传统疗法无反应。电休克疗法（ECT）可能有效，但其机制尚未完全了解。本研究采用功能近红外光谱（fNIRS）来探索ECT在一名MDD患者中引起的神经生物学变化，旨在阐明其治疗效果。
本研究采用fNIRS评估MDD患者与对照组之间的差异，并检查ECT后大脑血流动力学和脑网络节点的变化，以阐明治疗机制。
26名年龄和性别匹配的对照组和一名MDD男性患者在言语流畅性任务期间接受fNIRS检查。该患者接受了ECT治疗，并在治疗后动态评估感兴趣区域（ROIs）的β值、积分值和质心值。ECT后还进行了静息态fNIRS和功能连接性评估。
在基线时，MDD患者与对照组相比，血流动力学指标和功能连接性显著降低。ECT后，观察到这些指标的动态变化，趋向于正常化，且与对照组无显著差异。
fNIRS指标证明，ECT可改变抑郁症患者的大脑血流动力学和功能连接性。本研究强调了fNIRS在ECT治疗中进行客观神经生物学监测的实用性。
