11C-Pittsburgh 化合物 B PET 图像视觉解读简化参数方法的比较。
Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images.
机构信息
Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; and
Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; and.
出版信息
J Nucl Med. 2014 Aug;55(8):1305-7. doi: 10.2967/jnumed.114.139121. Epub 2014 Jun 4.
UNLABELLED
This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B ((11)C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups.
METHODS
Dynamic (11)C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined.
RESULTS
Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance.
CONCLUSION
The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of (11)C-PIB PET scans.
本研究比较了几种参数成像方法，以确定评估皮质淀粉样蛋白沉积的最佳方法，这些方法用于视觉评估不同记忆门诊患者群体的匹兹堡化合物 B ((11)C-PIB) PET 图像。
方法
对 120 名记忆门诊患者进行了动态 (11)C-PIB 扫描。将参数不可置换结合势 (BPND) 图像与标准化摄取值 (SUV) 和 SUV 比值图像进行比较。由 3 位独立的读者进行图像的视觉评估，并确定了读者间和方法间的一致性。
结果
90 分钟 (Fleiss κ = 0.88) 和 60 分钟 (Fleiss κ = 0.89) 的 BPND 图像均显示出良好的读者间一致性，而 SUV 比值图像 (Fleiss κ = 0.68) 和 SUV 图像 (Fleiss κ = 0.59) 的一致性则为良好至中度。尽管 BPND 图像始终表现出最佳性能，但读者间的方法间一致性差异很大。
结论
BPND 图像的使用提供了最高的读者间和方法间一致性，因此是最佳视觉解释 (11)C-PIB PET 扫描的首选方法。
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