Izumikawa Koichi, Inaba Tomoki, Mizukawa Shou, Kawai Yusuke, Sakakihara Ichiro, Ishikawa Shigenao, Miyoshi Masatsugu, Wato Masaki, Kawai Kozo
Department of Gastroenterology, Kagawa Prefectural Central Hospital.
Nihon Shokakibyo Gakkai Zasshi. 2014 Jun;111(6):1096-104.
Here we report two cases of dabigatran-induced esophageal ulcer. Case 1 was a 67-year-old man who presented with heartburn that developed a month after dabigatran administration. Case 2 was an 81-year-old woman who presented with epigastralgia that developed within a few days of dabigatran administration. Endoscopic findings were similar in both cases, including shallow esophageal ulcers covered with a thin whitish membrane. The patients were advised to consume the drug with plenty of water during meals and to remain in a sitting position for 30 min after consumption. This method successfully decreased their symptoms and ulcers, indicating that drug administration guidance is extremely effective in managing dabigatran-induced esophageal injury.
在此，我们报告两例达比加群酯所致食管溃疡的病例。病例1为一名67岁男性，在服用达比加群酯一个月后出现烧心症状。病例2为一名81岁女性，在服用达比加群酯几天后出现上腹部疼痛。两例患者的内镜检查结果相似，均可见覆盖有薄白色膜的浅表食管溃疡。建议患者在进餐时用大量水送服药物，并在服药后保持坐姿30分钟。该方法成功减轻了他们的症状和溃疡，表明给药指导在处理达比加群酯所致食管损伤方面极为有效。
