1] School of Psychological Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel [2] Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel.
1] Department of Communication Disorders, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel [2] Hearing, Speech, and Language Center, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Nat Commun. 2014 Jun 5;5:4059. doi: 10.1038/ncomms5059.
Performing actions with auditory consequences modulates the response in auditory cortex to otherwise identical stimuli passively heard. Such modulation has been suggested to occur through a corollary discharge sent from the motor cortex during voluntary actions. However, the relationship between the effector used to generate the sound, type of modulation and changes in perceptual sensitivity are unclear. Here we use functional magnetic resonance imaging on healthy subjects and demonstrate bilateral enhancement in the auditory cortex to self-generated versus externally generated sounds. Furthermore, we find that this enhancement is stronger when the sound-producing hand is contralateral to the auditory cortex. At the behavioural level, binaural hearing thresholds are lower for self-generated sounds and monaural thresholds are lower for sounds triggered by the hand ipsilateral to the stimulated ear. Together with functional connectivity analysis, our results suggest that a corollary discharge sent from active motor cortex enhances activity in the auditory cortex and increases perceptual sensitivity in a lateralized manner.
执行带有听觉后果的动作会调节对被动听到的其他相同刺激的听觉皮层的反应。这种调制被认为是通过在自愿动作期间从运动皮层发送的伴随放电来发生的。然而，用于产生声音的效应器、调制的类型和感知灵敏度的变化之间的关系尚不清楚。在这里，我们使用健康受试者的功能磁共振成像，证明了与外部产生的声音相比，自产生的声音在听觉皮层中双侧增强。此外，我们发现当产生声音的手与听觉皮层对侧时，这种增强更强。在行为水平上，自产生声音的双耳听力阈值较低，而对侧耳朵刺激时由手触发的声音的单耳阈值较低。结合功能连接分析，我们的结果表明，从活跃的运动皮层发出的伴随放电增强了听觉皮层的活动，并以偏侧化的方式提高了感知灵敏度。
