de Azevedo Cardoso Taiane, Mondin Thaise Campos, Wiener Carolina David, Marques Melina Bazili, Fucolo Briane de Ávila, Pinheiro Ricardo Tavares, de Souza Luciano Dias Mattos, da Silva Ricardo Azevedo, Jansen Karen, Oses Jean Pierre
Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Jean Pierre Oses, Rua Gonçalves Chaves 373, Sala 418C, Centro, Pelotas, CEP 96015-560, Brazil.
Neurochem Res. 2014 Aug;39(8):1571-8. doi: 10.1007/s11064-014-1349-4. Epub 2014 Jun 5.
Recent studies have evaluated the role of brain-derived neurotrophic factor (BDNF) in mood disorders; however, little is known about alterations in nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF). The aim of this study was to evaluate differences among serum neurotrophic factors (BDNF, NGF and GDNF) in depressed patients and healthy controls and to verify the association between serum neurotrophic levels and clinical characteristics in a young, depressed population stratified by gender. This is a cross-sectional study with depressed patients and population controls 18-29 years of age. The concentrations of neurotrophic factors were determined by the ELISA method. The diagnosis of depression and the duration of the disease were assessed by the Structured Clinical Interview according to the diagnostic and statistical manual of mental disorders. Depression severity was measured with the 17-item Hamilton Rating Scale for Depression, and the severity of anxiety symptoms was measured using the Hamilton Anxiety Rating Scale. Serum BDNF and GDNF were lower in major depressive disorder (MDD) patients compared to controls (p ≤ 0.001). Serum NGF levels were higher in MDD patients versus controls (p ≤ 0.001). BDNF was associated with the duration of disease only in women (p = 0.005). GDNF was not associated with clinical characteristics in either gender. In women, NGF was associated with the severity of depressive symptoms (p = 0.009), anxiety (p = 0.011) and disease duration (p = 0.005). NGF was associated with disease duration in men (p = 0.026). Our results demonstrated that significant neurochemical differences in NGF and BDNF, but not in GDNF, were associated with the clinical features of MDD when patients were stratified by gender.
近期研究评估了脑源性神经营养因子（BDNF）在情绪障碍中的作用；然而，关于神经生长因子（NGF）和胶质细胞系源性神经营养因子（GDNF）的改变却知之甚少。本研究的目的是评估抑郁症患者与健康对照者血清神经营养因子（BDNF、NGF和GDNF）之间的差异，并验证在按性别分层的年轻抑郁症患者群体中血清神经营养水平与临床特征之间的关联。这是一项针对18至29岁抑郁症患者和人群对照的横断面研究。采用酶联免疫吸附测定法（ELISA法）测定神经营养因子的浓度。根据《精神障碍诊断与统计手册》，通过结构化临床访谈评估抑郁症的诊断和病程。使用17项汉密尔顿抑郁评定量表测量抑郁严重程度，使用汉密尔顿焦虑评定量表测量焦虑症状的严重程度。与对照组相比，重度抑郁症（MDD）患者的血清BDNF和GDNF水平较低（p≤0.001）。MDD患者的血清NGF水平高于对照组（p≤0.001）。BDNF仅在女性中与病程相关（p = 0.005）。GDNF在任何性别中均与临床特征无关。在女性中，NGF与抑郁症状的严重程度（p = 0.009）、焦虑（p = 0.011）和病程（p = 0.005）相关。NGF在男性中与病程相关（p = 0.026）。我们的结果表明，当按性别对患者进行分层时，NGF和BDNF存在显著的神经化学差异，但GDNF没有，这些差异与MDD的临床特征相关。
