University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.
1] University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK. [2] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Nature. 2014 Jun 5;510(7503):76-83. doi: 10.1038/nature13477.
Our understanding of adipose tissue biology has progressed rapidly since the turn of the century. White adipose tissue has emerged as a key determinant of healthy metabolism and metabolic dysfunction. This realization is paralleled only by the confirmation that adult humans have heat-dissipating brown adipose tissue, an important contributor to energy balance and a possible therapeutic target for the treatment of metabolic disease. We propose that the development of successful strategies to target brown and white adipose tissues will depend on investigations that elucidate their developmental origins and cell-type-specific functional regulators.
自本世纪初以来，我们对脂肪组织生物学的理解取得了飞速发展。白色脂肪组织已成为健康代谢和代谢功能障碍的关键决定因素。这一认识与成年人具有散热的棕色脂肪组织这一事实相呼应，棕色脂肪组织是能量平衡的重要贡献者，也是治疗代谢性疾病的潜在治疗靶点。我们提出，成功靶向棕色和白色脂肪组织的策略的发展将取决于阐明其发育起源和细胞类型特异性功能调节剂的研究。
