Kaplan Jonah A, Lei Hongyi, Liu Rong, Padera Robert, Colson Yolonda L, Grinstaff Mark W
Departments of Biomedical Engineering and Chemistry, Boston University , Boston, Massachusetts 02215, United States.
Biomacromolecules. 2014 Jul 14;15(7):2548-54. doi: 10.1021/bm500410h. Epub 2014 Jun 20.
The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.
据报道，合成了一系列新型聚（乳酸 - 硬脂酸甘油单酯）（PLA - PGC18）共聚物，并将其用作可生物降解的聚合物掺杂剂，以提高聚（乳酸 - 乙醇酸）（PLGA）非织造网的疏水性。将PLGA溶液用PLA - PGC18掺杂并进行电纺丝，以形成具有微米级纤维的网。纤维直径、掺杂百分比和共聚物组成会影响网的不润湿性，并改变其机械（拉伸）性能。使用30%的聚合物掺杂剂可获得高达160°的接触角。最后，通过NIH/3T3细胞生物相容性试验确定，这些网无毒，并且在植入小鼠体内时显示出最小的异物反应。总之，描述了一种构建具有可调疏水性的可生物降解纤维网的通用方法，用于组织工程和药物递送应用。
