拉科酰胺的全合成。
Total synthesis of lacosamide.
作者信息
Stecko Sebastian
机构信息
Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/52, 01-224 Warsaw, Poland.
出版信息
J Org Chem. 2014 Jul 3;79(13):6342-6. doi: 10.1021/jo500857t. Epub 2014 Jun 12.
PMID:24901295
Abstract
Total synthesis of anticonvulsant amino acid, lacosamide, is reported. The key step is stereospecific allyl cyanate-to-isocyanate rearrangement, which proceeds with chirality transfer. The enantiopure starting material for the rearrangement step was accessed from ethyl L-lactate.
摘要
据报道，抗惊厥氨基酸拉科酰胺已实现全合成。关键步骤是立体特异性的烯丙基氰酸酯到异氰酸酯的重排反应，该反应伴随着手性转移。重排步骤的对映体纯起始原料是由L-乳酸乙酯制得的。
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