Veerendranath Pesala, Donovan Les, Taneja Mukesh, Naduvilath Thomas John, Garrett Qian, Delgado Stephanie, Sangwan Virender S, Ho Arthur
*BSc(Optom) †BOptom ‡DNB §PhD ∥BSc **MS ††PhD, FAAO L V Prasad Eye Institute, Hyderabad, India (PV, MT, VSS); Vision Cooperative Research Centre, Sydney, New South Wales, Australia (PV, MT, QG, SD, VSS); Brien Holden Vision Institute, New South Wales, Australia (LD, TJN, QG, SD, AH); School of Optometry and Vision Science, University of New South Wales, New South Wales, Australia (QG, AH); and Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida (AH).
Optom Vis Sci. 2014 Jul;91(7):752-9. doi: 10.1097/OPX.0000000000000294.
To measure the accommodative response in unsighted or profoundly vision impaired (PVI) eyes when accommodation is elicited in the fellow, sighted eye.
Eighty-eight unilaterally PVI subjects (UPS) and 97 bilaterally sighted subjects (BSS) (10 to 45 years) were enrolled. Subjects had clear ocular media for auto-refraction and could steadily fixate targets with the sighted eye. For BSS, a long-pass filter was placed in front of one eye to simulate unilateral blindness. Both eyes were measured with a Shin-Nippon auto-refractor while fixating a 4/40 letter at 4 m and then an N8 letter at 40 cm and at 33 cm. Accommodation was calculated as the difference between distance and near refraction.
Only subjects with repeatable alignment between measurements were included in the analyses (64 UPS, 95 BSS). Results were analyzed using t test and a generalized linear mixed model including age, sightedness, distance spherical equivalent, and accommodation as factors. The t test found no significant difference between eyes for UPS (p = 0.981 at 40 cm and p = 0.663 at 33 cm). For BSS, the sighting eye produced statistically significant but only slightly greater amounts of accommodation than the filtered eye (0.098 diopters [D], p = 0.002 at 40 cm and 0.189 D, p < 0.001 at 33 cm). The generalized linear mixed model found no difference between BSS and UPS in terms of difference in accommodation between eyes (p = 0.128 at 40 cm and p = 0.157 at 33 cm).
The PVI eyes of unilaterally PVI individuals display similar accommodative response to their fellow, sighted eyes when accommodation is elicited by near target of up to 3 D to the fellow eye. However, the difference in accommodative response between PVI and fellow, sighted eye is related to the amount of accommodation elicited.
当健眼引发调节时，测量盲眼或严重视力受损（PVI）眼的调节反应。
纳入88名单侧PVI受试者（UPS）和97名双眼视力正常受试者（BSS）（年龄10至45岁）。受试者眼部介质清晰，可进行自动验光，且健眼能稳定注视目标。对于BSS，在一只眼前放置长波滤光片以模拟单眼失明。在注视4米处的4/40字母，然后注视40厘米和33厘米处的N8字母时，使用日本新光自动验光仪测量双眼。调节力通过远距离和近距离验光的差值计算得出。
分析仅纳入测量结果可重复对齐的受试者（64名UPS，95名BSS）。使用t检验和广义线性混合模型分析结果，模型因素包括年龄、视力、远距离球镜等效度和调节力。t检验发现UPS两眼之间无显著差异（40厘米处p = 0.981，33厘米处p = 0.663）。对于BSS，注视眼产生的调节力在统计学上有显著差异，但仅略高于滤光片遮挡眼（40厘米处为0.098屈光度[D]，p = 0.002；33厘米处为0.189 D，p < 0.001）。广义线性混合模型发现，BSS和UPS两眼之间调节力差异无差异（40厘米处p = 0.128，33厘米处p = 0.157）。
当健眼通过高达3 D的近距离目标引发调节时，单侧PVI个体的PVI眼与健眼表现出相似的调节反应。然而，PVI眼与健眼之间调节反应的差异与引发的调节量有关。
