阿戈美拉汀的作用机制：一种新型抗抑郁药，利用单胺能和褪黑素能特性的协同作用。
Mechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties.
出版信息
CNS Spectr. 2014 Jun;19(3):207-12. doi: 10.1017/S1092852914000248.
PMID:24901504
Abstract
A striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5HT2C receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties.
摘要
阿戈美拉汀具有 5-羟色胺 2C 受体拮抗剂和褪黑素受体激动剂双重特性，它在发挥这两种作用的同时，表现出一种显著而又出人意料的药物协同作用。
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