独立的非语言测量方法能否预测人工耳蜗植入的 candidacy？ （注：这里“candidacy”直译为“候选资格”，结合语境可能不太好理解其确切意思，整体句子理解为“独立的非语言测量方法能否预测适合人工耳蜗植入的情况”会更通顺，但需按照要求不能添加解释，所以保留原词。）
Can unaided non-linguistic measures predict cochlear implant candidacy?
作者信息
Shim Hyun Joon, Won Jong Ho, Moon Il Joon, Anderson Elizabeth S, Drennan Ward R, McIntosh Nancy E, Weaver Edward M, Rubinstein Jay T
机构信息
*Department of Otorhinolaryngology, Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea; †Department of Audiology and Speech Pathology, University of Tennessee Health Science Center, Knoxville, Tennessee, U.S.A.; ‡Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea; §Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, U.S.A.; ∥Envoy Medical Corporation, St. Paul, Minnesota, U.S.A.; and ¶Comparative Effectiveness, Cost and Outcomes Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, U.S.A.
出版信息
Otol Neurotol. 2014 Sep;35(8):1345-53. doi: 10.1097/MAO.0000000000000323.
OBJECTIVE
To determine if unaided, non-linguistic psychoacoustic measures can be effective in evaluating cochlear implant (CI) candidacy.
STUDY DESIGN
Prospective split-cohort study including predictor development subgroup and independent predictor validation subgroup.
SETTING
Tertiary referral center.
SUBJECTS
Fifteen subjects (28 ears) with hearing loss were recruited from patients visiting the University of Washington Medical Center for CI evaluation.
METHODS
Spectral-ripple discrimination (using a 13-dB modulation depth) and temporal modulation detection using 10- and 100-Hz modulation frequencies were assessed with stimuli presented through insert earphones. Correlations between performance for psychoacoustic tasks and speech perception tasks were assessed. Receiver operating characteristic curve analysis was performed to estimate the optimal psychoacoustic score for CI candidacy evaluation in the development subgroup and then tested in an independent sample.
RESULTS
Strong correlations were observed between spectral-ripple thresholds and both aided sentence recognition and unaided word recognition. Weaker relationships were found between temporal modulation detection and speech tests. Receiver operating characteristic curve analysis demonstrated that the unaided spectral-ripple discrimination shows a good sensitivity, specificity, positive predictive value, and negative predictive value compared to the current gold standard, aided sentence recognition.
CONCLUSION
Results demonstrated that the unaided spectral-ripple discrimination test could be a promising tool for evaluating CI candidacy.
目的
确定独立的非语言心理声学测量方法是否能有效评估人工耳蜗（CI）植入的适宜性。
研究设计
前瞻性分组队列研究，包括预测指标开发亚组和独立预测指标验证亚组。
研究地点
三级转诊中心。
研究对象
从前往华盛顿大学医学中心进行CI评估的患者中招募了15名听力损失患者（28只耳）。
方法
通过插入式耳机呈现刺激，评估频谱纹波辨别（使用13 dB调制深度）以及使用10 Hz和100 Hz调制频率的时间调制检测。评估心理声学任务表现与言语感知任务表现之间的相关性。进行受试者操作特征曲线分析，以估计在开发亚组中用于CI植入适宜性评估的最佳心理声学分数，然后在独立样本中进行测试。
结果
观察到频谱纹波阈值与助听句子识别和非助听单词识别之间存在强相关性。在时间调制检测与言语测试之间发现较弱的关系。受试者操作特征曲线分析表明，与当前的金标准助听句子识别相比，非助听频谱纹波辨别具有良好的敏感性、特异性、阳性预测值和阴性预测值。
结论
结果表明，非助听频谱纹波辨别测试可能是评估CI植入适宜性的一种有前景的工具。
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