Razi Ebrahim, Razi Armin, Moosavi Gholam Abbas
Trauma Research Center, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Department of Internal Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2014;52(3):192-6.
Increases in body mass index (BMI) are reported to influence asthma response to treatment. The aim of this study was to investigate the relationship between BMI and response to treatment in a group of patients that were referred for asthma control. Effectiveness measurements in this analysis included percentage of changes in forced volume in 1 second (FEV1), forced volume capacity (FVC), FEV1/FVC, and forced expiratory flow between 25% and 75% of FVC (FEF25-75%). A total of 293 subjects with asthma of both genders and above 18 years of age were divided into the following BMI categories: 107 (36.5%) non-obese (BMI < 25), 186 (63.5%) overweight and obese (BMI ≥ 25). Percentage of change was defined as change in variable between baseline and end-of-treatment. Analyses of non-obese vs. overweight/obese asthmatics demonstrated non-significant differences in baseline FEV1 (1.62 ± 0.56 Lit vs. 1.63 ± 0.56 Lit L, P = 0.89); FVC (2.58 ± 0.73 Lit vs. 2.47 ± 0.82 Lit, P = 0.25); and FEF25-75% (1.04 ± 0.55 ml/sec vs. 1.05 ± 0.50 ml/sec, P = 0.47) respectively. Compared with non-obese subjects, in overweight/obese subjects with asthma were less responded to treatment. Percentage changes of FEV1, FVC, FEF25-75%, and FEV1/FVC in non-obese versus obese/overweight patients were: 79.57 ± 55.14 % vs. 62.13 ± 41.72%, P = 0.005; 47.71 ± 33.76% vs. 39.93 ± 28.30%, P = 0.036; 151.98 ± 127.82% vs. 123 ± 91.12%, P = 0.041; 20.54 ± 15.63% vs. 15.63 ± 11.32%, P = 0.005; respectively. Percentage changes of spirometric values to treatment in over weight/obese asthmatic patient were lesser in compared with non-obese subjects.
据报道，体重指数（BMI）的增加会影响哮喘的治疗反应。本研究的目的是调查一组因哮喘控制而转诊的患者中BMI与治疗反应之间的关系。该分析中的有效性测量包括1秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC以及FVC的25%至75%之间的用力呼气流量（FEF25-75%）的变化百分比。共有293名18岁以上的哮喘患者被分为以下BMI类别：107名（36.5%）非肥胖者（BMI<25），186名（63.5%）超重和肥胖者（BMI≥25）。变化百分比定义为基线与治疗结束之间变量的变化。非肥胖与超重/肥胖哮喘患者的分析显示，基线FEV1（1.62±0.56升与1.63±0.56升，P=0.89）、FVC（2.58±0.73升与2.47±0.82升，P=0.25）和FEF25-75%（1.04±0.55毫升/秒与1.05±0.50毫升/秒，P=0.47）之间无显著差异。与非肥胖受试者相比，超重/肥胖哮喘受试者对治疗的反应较差。非肥胖与肥胖/超重患者中FEV1、FVC、FEF25-75%和FEV1/FVC的变化百分比分别为：79.57±55.14%与62.13±41.72%，P=0.005；47.71±33.76%与39.93±28.30%，P=0.036；151.98±127.82%与123±91.12%，P=0.041；20.54±15.63%与15.63±11.32%，P=0.005。与非肥胖受试者相比，超重/肥胖哮喘患者治疗后肺功能值的变化百分比更小。
