Zochodne Douglas W
Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary , 2500 University Drive NW, Calgary, Alberta T2N 4N1, Canada.
ACS Chem Neurosci. 2014 Aug 20;5(8):618-20. doi: 10.1021/cn500110p. Epub 2014 Jun 5.
Neurons choose growth pathways with half hearted reluctance, behavior that may be appropriate to maintain fixed long lasting connections but not to regenerate them. We now recognize that intrinsic brakes on regrowth are widely expressed in these hesitant neurons and include classical tumor suppressor molecules. Here, we review how two brakes, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and retinoblastoma emerge as new and exciting knockdown targets to enhance neuron plasticity and improve outcome from damage or disease.
神经元选择生长路径时犹豫不决，这种行为或许适合维持固定的长期连接，但不适合再生这些连接。我们现在认识到，在这些迟疑的神经元中广泛表达着对再生的内在抑制因素，其中包括经典的肿瘤抑制分子。在此，我们综述了两种抑制因素——第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）以及视网膜母细胞瘤蛋白——如何成为增强神经元可塑性、改善损伤或疾病预后的新的且令人振奋的基因敲低靶点。
