Moosazadeh Mahmood, Amiresmaili Mohammadreza, Aliramezany Maryam
Department of Epidemiology, Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Department of Health services management, Research Center for Health Services Management, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Acta Med Iran. 2014;52(4):256-64.
Search results show that numerous primary studies have been carried out in different parts of Iran regarding prevalence of G6PD deficiency; if results of these studies are combined, a reliable estimation of prevalence of this factor will be achieved in Iran. Thus, present study, aimed to determine the prevalence of G6PD deficiency by combining findings of qualified primary studies using meta-analysis and taking into account heterogeneity considerations. Searching the relevant keywords in Iranian and International databases, primary studies were selected. After quality appraisal and applying inclusion and exclusion criteria, relevant primary studies were selected. In each study, standard error of prevalence of G6PD was calculated according to binominal distribution formula. Finally, heterogeneity index was determined among studies using Cochran's test. Prevalence of G6PD in Iran was estimated by STATA software ver 11 using fixed or random effect model based on heterogeneity results. 148916 subjects in 36 primary studies which entered this meta-analysis were examined. G6PD deficiency prevalence was 6.7% in Iran (men: 8.8% and women: 2.2%). Also, this deficiency in the present study was four times higher in men than in women. Its prevalence was adjusted in different parts of Iran and it was shown that it was between 0.8 and 15.2 using Bayesian analysis. This meta-analysis showed that Iran is among countries with high frequency of G6PD deficiency and there is a significant difference in prevalence of G6PD in different parts of Iran. According to these results, screening newborn children seems very vital. Carrying out other primary studies regarding prevalence of G6PD seems unnecessary.
搜索结果显示，伊朗不同地区已开展了大量关于葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症患病率的初步研究；如果将这些研究结果合并，将能够可靠地估计伊朗该因素的患病率。因此，本研究旨在通过荟萃分析合并合格的初步研究结果，并考虑异质性因素，来确定G6PD缺乏症的患病率。在伊朗和国际数据库中搜索相关关键词，筛选出初步研究。在进行质量评估并应用纳入和排除标准后，选取了相关的初步研究。在每项研究中，根据二项分布公式计算G6PD患病率的标准误差。最后，使用 Cochr an检验确定各研究之间的异质性指数。使用STATA软件11版，根据异质性结果，采用固定效应模型或随机效应模型估计伊朗的G6PD患病率。本荟萃分析纳入了36项初步研究中的148916名受试者。伊朗G6PD缺乏症的患病率为6.7%（男性：8.8%，女性：2.2%）。此外，本研究中该缺乏症在男性中的患病率是女性的四倍。对伊朗不同地区的患病率进行了调整，结果显示，使用贝叶斯分析，患病率在0.8%至15.2%之间。这项荟萃分析表明，伊朗是G6PD缺乏症高发国家之一，且伊朗不同地区的G6PD患病率存在显著差异。根据这些结果，对新生儿进行筛查似乎至关重要。开展其他关于G6PD患病率的初步研究似乎没有必要。
