Zis Panagiotis, McHugh Patrick, McQuillin Andrew, Praticò Domenico, Dickinson Mark, Shende Sima, Walker Zuzana, Strydom Andre
University College London, Division of Psychiatry, London, United Kingdom.
Division of Pharmacy and Pharmaceutical Sciences, School of Applied Sciences University of Huddersfield, Queensgate, Huddersfield, United Kingdom.
PLoS One. 2014 Jun 5;9(6):e97709. doi: 10.1371/journal.pone.0097709. eCollection 2014.
Lipid peroxidation may be a marker of free-radical-mediated injury associated with Alzheimer's disease (AD). We aimed to investigate whether changes in lipid peroxidation is associated with cognitive decline in individuals with Down syndrome over a 4-year period.
Thirty-two adults with DS participated in a longitudinal study with urinary isoprostane 8,12-iso-iPF2alpha (iPF2alpha) assays at baseline and four years follow-up. Informants rated their functional ability and memory function and the adults with DS attempted assessments of language skills and memory. Twenty-six individuals completed assessments of memory (Modified Memory Object Task, MOMT), adaptive behavior (ABAS), and receptive vocabulary (British Picture vocabulary, BPVS) at both time-points.
Overall change in iPF2alpha level was negatively correlated with change in the MOMT score (Spearman's Rho = -0.576, p = 0.006), i.e., increased lipid peroxidation was correlated with worse memory functioning over time. An increase of ≥ 0.02 ng/mg creatinine iPF2α had good sensitivity (85.7%), positive predictive value (75%,), specificity (85.7%) and negative predictive value (92.3%) for memory decline.
Change in iPF2alpha over time may have potential as a biomarker for memory decline in Down syndrome and potentially also help to track progression of MCI to AD in the general population.
脂质过氧化可能是与阿尔茨海默病（AD）相关的自由基介导损伤的一个标志物。我们旨在调查在4年时间里，脂质过氧化的变化是否与唐氏综合征患者的认知衰退相关。
32名患有唐氏综合征的成年人参与了一项纵向研究，在基线和4年随访时进行尿中异前列腺素8,12-异-iPF2α（iPF2α）检测。 informant对他们的功能能力和记忆功能进行评分，患有唐氏综合征的成年人尝试进行语言技能和记忆评估。26名个体在两个时间点均完成了记忆（改良记忆物体任务，MOMT）、适应性行为（ABAS）和接受性词汇（英国图片词汇量表，BPVS）评估。
iPF2α水平的总体变化与MOMT评分的变化呈负相关（斯皮尔曼等级相关系数= -0.576，p = 0.006），即随着时间推移，脂质过氧化增加与记忆功能较差相关。iPF2α每增加≥0.02 ng/mg肌酐对记忆衰退具有良好的敏感性（85.7%）、阳性预测值（75%）、特异性（85.7%）和阴性预测值（92.3%）。
随着时间推移，iPF2α的变化可能有潜力作为唐氏综合征患者记忆衰退的生物标志物，也可能有助于在一般人群中追踪轻度认知障碍向阿尔茨海默病的进展。
