Zis Panagiotis, Strydom André, Buckley David, Adekitan Daniel, McHugh Patrick C
University College London, Division of Psychiatry, London, United Kingdom; Sheffield Teaching Hospitals NHS Trust, Department of Neurology, Sheffield, United Kingdom.
University College London, Division of Psychiatry, London, United Kingdom; The LonDowns Consortium, United Kingdom.
Neurosci Lett. 2017 Jan 1;636:254-257. doi: 10.1016/j.neulet.2016.11.023. Epub 2016 Nov 13.
Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS).
Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS).
Neopterin/creatinine levels were negatively correlated with change in the MOMT total score (Spearman's Rho=-0.517, p=0.020) and change in the MOMT delayed recall score (Spearman's Rho=-0.577, p=0.008) over time, i.e. higher neopterin/creatinine level was associated with worse performance on a test of cognitive ability over time.
Urine neopterin may have potential as a biomarker for memory decline in Down syndrome, and could potentially also help to track progression of mild cognitive impairment (MCI) to Alzheimer's disease in other high risk populations.
新蝶呤是一种未结合的蝶啶，由活化的巨噬细胞大量分泌，可作为活化细胞免疫和氧化应激的临床标志物。我们旨在研究唐氏综合征（DS）患者的尿新蝶呤水平是否与认知功能相关。
最初参与一项纵向研究的32名成年DS患者中，25名在4年后接受了随访。信息提供者对他们的适应性行为进行评分（ABAS），成年DS患者在基线和随访时间点尝试进行语言技能和记忆评估（改良记忆物体任务，MOMT）以及接受性词汇评估（英国图片词汇量表，BPVS）。
随着时间的推移，新蝶呤/肌酐水平与MOMT总分的变化（Spearman相关系数=-0.517，p=0.020）以及MOMT延迟回忆分数的变化（Spearman相关系数=-0.577，p=0.008）呈负相关，即随着时间的推移，新蝶呤/肌酐水平越高，认知能力测试的表现越差。
尿新蝶呤可能有潜力作为唐氏综合征记忆衰退的生物标志物，也可能有助于追踪其他高危人群中轻度认知障碍（MCI）向阿尔茨海默病的进展。
