Zhang Jie, Cai Shifeng, Li Changzhong, Sun Xichao, Han Xue, Yang Chunrun, Fu Caixia, Liu Qingwei, Xin Yinghui, Zong Yuanyuan
Department of Radiology, Shandong Provincial Hospital, Shandong University, 324# Jingwu Weiqi road, Jinan, People's Republic of China.
Eur Radiol. 2014 Oct;24(10):2552-60. doi: 10.1007/s00330-014-3237-3. Epub 2014 Jun 6.
To investigate whether the choline-containing compounds (Cho) obtained from three-dimensional (1)H magnetic resonance (MR) spectroscopy can differentiate endometrial cancer (ECa) from benign lesions in endometria or in submucosa (BLs-ESm) and is associated with the aggressiveness of ECa.
Fifty-seven patients (ECa, 38; BLs-ESm, 19) underwent preoperative multi-voxel MR spectroscopy at 3.0 T. The ratio of the sum of the Cho peak integral to the sum of the unsuppressed water peak integral (Cho/water) and the coefficient of variation (CV) used to describe the variability of Cho/water in one lesion were calculated.
Mean Cho/water (±standard deviation [SD]) was (3.02 ± 1.43) × 10(-3) for ECa and (1.68 ± 0.33) × 10(-3) for BLs-ESm (p < 0.001). Mean Cho/water was (4.42 ± 1.53) × 10(-3) for type II ECa and (2.65 ± 1.17) × 10(-3) for type I ECa (p = 0.001). There were no significant differences among different stages of ECa (p = 0.107) or different grades of ECa (p = 0.142). The Cho/water was positively correlated with tumour stage (r = 0.386, p = 0.017) and size (r = 0.333, p = 0.041). The CV was also positively correlated with tumour stage (r = 0.537, p = 0.001) and size (r = 0.34, p = 0.037).
The Cho/water can differentiate ECa from BLs-ESm and differentiate type II from type I ECa, but cannot differentiate different stages of ECa or different grades of ECa. Cho/water increased with the increase of tumour stage and size.
• First report to attempt to assess ECa aggressiveness with magnetic resonance spectroscopy (MRS). • MRS can differentiate type I from type II ECa. • MRS can differentiate ECa from BLs-ESm. • MRS cannot differentiate different stages of ECa or different grades of ECa. • Cho/water increased with the increase of tumour stage and size.
研究通过三维氢磁共振波谱法获得的含胆碱化合物（Cho）能否区分子宫内膜癌（ECa）与子宫内膜或黏膜下良性病变（BLs - ESm），以及其是否与ECa的侵袭性相关。
57例患者（ECa患者38例；BLs - ESm患者19例）在3.0 T磁场下术前行多体素磁共振波谱检查。计算Cho峰积分总和与未抑制水峰积分总和的比值（Cho/水）以及用于描述一个病变中Cho/水变异性的变异系数（CV）。
ECa患者的平均Cho/水（±标准差[SD]）为(3.02±1.43)×10⁻³，BLs - ESm患者为(1.68±0.33)×10⁻³（p<0.001）。II型ECa患者的平均Cho/水为(4.42±1.53)×10⁻³，I型ECa患者为(2.65±1.17)×10⁻³（p = 0.001）。ECa不同分期（p = 0.107）或不同分级（p = 0.142）之间无显著差异。Cho/水与肿瘤分期（r = 0.386，p = 0.017）和大小（r = 0.333，p = 0.041）呈正相关。CV也与肿瘤分期（r = 0.537，p = 0.001）和大小（r = 0.34，p = 0.037）呈正相关。
Cho/水可区分ECa与BLs - ESm，区分II型与I型ECa，但不能区分ECa的不同分期或不同分级。Cho/水随肿瘤分期和大小增加而升高。
• 首次尝试用磁共振波谱法（MRS）评估ECa侵袭性的报告。• MRS可区分I型与II型ECa。• MRS可区分ECa与BLs - ESm。• MRS不能区分ECa的不同分期或不同分级。• Cho/水随肿瘤分期和大小增加而升高。
