基因、环境与非洲裔人群的心血管代谢疾病易感性
Genes, environment, and African ancestry in cardiometabolic disorders.
机构信息
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Trends Endocrinol Metab. 2023 Oct;34(10):601-621. doi: 10.1016/j.tem.2023.07.007. Epub 2023 Aug 17.
The past two decades have been characterized by a substantial global increase in cardiometabolic diseases, but the prevalence and incidence of these diseases and related traits differ across populations. African ancestry populations are among the most affected yet least included in research. Populations of African descent manifest significant genetic and environmental diversity and this under-representation is a missed opportunity for discovery and could exacerbate existing health disparities and curtail equitable implementation of precision medicine. Here, we discuss cardiometabolic diseases and traits in the context of African descent populations, including both genetic and environmental contributors and emphasizing novel discoveries. We also review new initiatives to include more individuals of African descent in genomics to address current gaps in the field.
在过去的二十年中，心血管代谢疾病在全球范围内显著增加，但这些疾病及相关特征的流行率和发病率在不同人群中存在差异。非洲裔人群受影响最为严重，但在研究中却被严重忽视。非洲裔人群表现出显著的遗传和环境多样性，但这种代表性不足是发现的错失机会，可能会加剧现有的健康差距，并限制精准医学的公平实施。在这里，我们将讨论非洲裔人群中的心血管代谢疾病和特征，包括遗传和环境因素，并强调新的发现。我们还回顾了新的举措，以纳入更多的非洲裔个体进行基因组学研究，从而解决该领域当前的差距。
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